Matlacha Isles Hotels, Cape Coral

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Check prices for these dates

Tonight
19 Dec - 20 Dec
Tomorrow
20 Dec - 21 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Matlacha Isles hotels

3 restaurants, breakfast, lunch, dinner served; Italian cuisine
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
23.2 km from Matlacha Isles
9.0 out of 10, Wonderful, (1016)
"Clean rooms, friendly staff, so much to do there and nearby "
United States
Lisa R
The price is AU$277
includes taxes & fees
22 Dec - 23 Dec
Lani Kai Beachfront Resort
Interior
Holiday Inn Express & Suites Fort Myers Airport by IHG

Holiday Inn Express & Suites Fort Myers Airport by IHG

Holiday Inn Express & Suites Fort Myers Airport by IHG
2.5 star property
29 km from Matlacha Isles
9.6 out of 10, Exceptional, (1010)
"Great stress-free stay"
United States
Kelly
The price is AU$185
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express & Suites Fort Myers Airport by IHG
Exterior
Best Western Fort Myers Inn & Suites

Best Western Fort Myers Inn & Suites

Best Western Fort Myers Inn & Suites
2.5 star property
20.8 km from Matlacha Isles
8.8 out of 10, Excellent, (1107)
"Clean room, friendly staff"
United States
Mary
The price is AU$135
includes taxes & fees
21 Dec - 22 Dec
Best Western Fort Myers Inn & Suites
Lobby
Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
2.0 star property
28 km from Matlacha Isles
8.0 out of 10, Very good, (1504)
"Nice and beautiful place to stay "
United States
Maguenne
The price is AU$134
includes taxes & fees
20 Dec - 21 Dec
Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
Indoor pool
Comfort Inn & Suites Fort Myers Airport

Comfort Inn & Suites Fort Myers Airport

Comfort Inn & Suites Fort Myers Airport
2.5 star property
27.9 km from Matlacha Isles
8.8 out of 10, Excellent, (1120)
"Great staff"
United States
Alison
The price is AU$150
includes taxes & fees
22 Dec - 23 Dec
Comfort Inn & Suites Fort Myers Airport
Sun deck
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
20.4 km from Matlacha Isles
8.8 out of 10, Excellent, (1001)
"Great Place to Stay!"
United States
JUDY
The price is AU$190
includes taxes & fees
21 Dec - 22 Dec
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Exterior
Hyatt Place Fort Myers/at The Forum

Hyatt Place Fort Myers/at The Forum

Hyatt Place Fort Myers/at The Forum
3.0 star property
24.7 km from Matlacha Isles
8.2 out of 10, Very good, (1000)
"Friendly staff, good breakfast good location."
United States
Lily
The price is AU$177
includes taxes & fees
21 Dec - 22 Dec
Hyatt Place Fort Myers/at The Forum
Bar (on property)
Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
20.6 km from Matlacha Isles
8.8 out of 10, Excellent, (1000)
"Very nice hotel"
United States
Ashley
The price is AU$215
includes taxes & fees
3 Jan - 4 Jan 2026
Doubletree by Hilton Fort Myers at Bell Tower Shops
Lobby
Baymont by Wyndham Punta Gorda/Port Charlotte

Baymont by Wyndham Punta Gorda/Port Charlotte

Baymont by Wyndham Punta Gorda/Port Charlotte
2.5 star property
29 km from Matlacha Isles
8.4 out of 10, Very good, (1134)
"Friendly staff, good breakfast. "
United States
Tom
The price is AU$136
includes taxes & fees
20 Dec - 21 Dec
Baymont by Wyndham Punta Gorda/Port Charlotte
Free daily buffet breakfast
Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
18.1 km from Matlacha Isles
8.6 out of 10, Excellent, (1000)
"The property was clean and the breakfast was excellent the staff was friendly and convenient to Sanibel Island"
United States
robert
The price is AU$174
includes taxes & fees
21 Dec - 22 Dec
Residence Inn by Marriott Fort Myers Sanibel
Lobby
Quality Suites Fort Myers I-75

Quality Suites Fort Myers I-75

Quality Suites Fort Myers I-75
2.5 star property
27 km from Matlacha Isles
8.0 out of 10, Very good, (1000)
"Clean place comfy beds "
United States
Todd
The price is AU$133
includes taxes & fees
21 Dec - 22 Dec
Quality Suites Fort Myers I-75
Exterior
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
19.9 km from Matlacha Isles
9.4 out of 10, Exceptional, (1001)
"Great rooms, good staff"
United States
Dedan
The price is AU$192
includes taxes & fees
23 Dec - 24 Dec
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Desk, iron/ironing board, free WiFi, bed sheets
Best Western Fort Myers Waterfront

Best Western Fort Myers Waterfront

Best Western Fort Myers Waterfront
3.0 star property
Hancock, 16.7 km from Matlacha Isles
7.4 out of 10, Good, (1004)
"Breakfast, and room better than expected "
United States
Brandi
The price is AU$171
includes taxes & fees
21 Dec - 22 Dec
Best Western Fort Myers Waterfront
BBQ/picnic Area
Home2 Suites by Hilton Fort Myers Colonial Blvd

Home2 Suites by Hilton Fort Myers Colonial Blvd

Home2 Suites by Hilton Fort Myers Colonial Blvd
3.0 star property
20.8 km from Matlacha Isles
9.4 out of 10, Exceptional, (572)
"I will stay there again "
United States
Karen
The price is AU$198
includes taxes & fees
22 Dec - 23 Dec
Home2 Suites by Hilton Fort Myers Colonial Blvd
Suite, 1 King Bed, Non Smoking
Comfort Inn Fort Myers Northeast

Comfort Inn Fort Myers Northeast

Comfort Inn Fort Myers Northeast
2.5 star property
25.7 km from Matlacha Isles
7.8 out of 10, Good, (665)
"Good clean rooms"
United States
Phillip
The price is AU$147
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn Fort Myers Northeast
1 King Bed Suite w/ Efficiency Non Smoking
Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral
2.0 star property
18.4 km from Matlacha Isles
7.6 out of 10, Good, (199)
"Microwave made an explosion when tried to use it. The rest amazing"
United States
Alain
The price is AU$136
includes taxes & fees
28 Dec - 29 Dec
Quality Inn Fort Myers Cape Coral
2 outdoor pools
The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
22.8 km from Matlacha Isles
8.6 out of 10, Excellent, (1569)
"Great resort fun bar beautiful pool walkable area variety of restaurants and clean beach"
United States
Erika
The Lighthouse Resort Inn & Suites
Floating Coconut Cottage Houseboat | Terrace/patio
Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
20.3 km from Matlacha Isles
8.6 out of 10, Excellent, (905)
"Wonderful stay at the property. It was hard to leave."
United States
Aaron
Latitude 26 Waterfront Resort & Marina
On the beach, sun-loungers, beach towels
Sanibel Island Beach Resort

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
22.7 km from Matlacha Isles
9.2 out of 10, Wonderful, (1471)
"Great place."
United States
Michael
The price is AU$446
includes taxes & fees
21 Dec - 22 Dec
Sanibel Island Beach Resort
Reception
Americas Best Value Inn Ft. Myers

Americas Best Value Inn Ft. Myers

Americas Best Value Inn Ft. Myers
3.0 star property
19.3 km from Matlacha Isles
7.6 out of 10, Good, (1122)
"Loved it. The staff was great rooms were clean. "
United States
Austin
The price is AU$116
includes taxes & fees
21 Dec - 22 Dec
Americas Best Value Inn Ft. Myers
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in Matlacha Isles

Find the best Matlacha Isles areas for the activities you enjoy most.

Pelican

While visiting Pelican, you might make a stop by sights like Tarpon Point and Harbour View Gallery.

Caloosahatchee

If you're spending some time in Caloosahatchee, Cape Coral Yacht Club Beach and Dolphin Marina are top sights worth seeing.

Yacht Club

While Yacht Club isn't home to many top sights, Cape Coral Yacht Club Beach and Dolphin Marina are some notable places to visit nearby.

Hancock

While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Pine Island Shopping Center.

Mariner

While visiting Mariner, you might make a stop by sights like Mike Greenwell's Bat-A-Ball & Family Fun Park and Yucca Pens Unit State Wildlife Management Area.

Top Matlacha Isles Hotel Reviews

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

10/10 Excellent
"Yes, the room was very clean. The staff was extremely helpful and pleasant. I would highly recommend staying at the Holiday Inn Express."
Carol 1-night trip
Posted 1 day ago
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Frequently asked questions

What is Matlacha Isles like?
Travellers will be sure to find plenty to entertain them in Cape Coral's Matlacha Isles neighbourhood.
How many hotels will I be able to find in the Matlacha Isles area?
When you want to put your feet up after a day of exploring the sights in Cape Coral, you can choose from 17 Expedia hotels and other accommodation options in Matlacha Isles.
If I need to cancel my hotel reservation in Matlacha Isles, will I receive a refund?
Yes, the majority of room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals in Matlacha Isles.
What are the top things to see and do in Matlacha Isles?
A few places to visit in the area around Matlacha Isles include Griffen American Center for Haitian Art, Lovegrove Gallery & Gardens and Royal Tee Golf Club. While you're out sightseeing in Cape Coral, make sure that you visit other sights such as Little Dead Key or Big Dead Key.