Default HTG hotel image

Top Hotels Near Florida Keys National Marine Sanctuary in Key West from AU$240

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
13 Oct - 14 Oct
Tomorrow
14 Oct - 15 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Filter by

Property class

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.
A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.
A swimming pool with lounge chairs, surrounded by palm trees and greenery.
A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

1. Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
John
AU$450
includes taxes & fees
27 Oct - 28 Oct
Almond Tree Inn Hotel - Adults Only
A tropical outdoor area with palm trees, hanging plants, and string lights.
An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.
A wooden deck with lush greenery and a pool area.
A large, two-story building with a balcony, surrounded by dense tropical foliage.

2. Douglas House - Adults Only

Douglas House - Adults Only
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
United States
Maricela
AU$280
includes taxes & fees
15 Oct - 16 Oct
Douglas House - Adults Only
A modern interior with a staircase, a sofa set, a wooden table, and a television.
A pathway flanked by lush green foliage leading to a gated entrance.
A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.
A spacious room with a large bed, a sofa, a chair, a small table, and a television.

3. Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
United States
William
AU$385
includes taxes & fees
25 Oct - 26 Oct
Simonton Court Historic Inn & Cottages
A modern outdoor area with a pool, lounge chairs, and a bar area.
A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.
A modern hotel room with a bed, sofa, coffee table, and artwork.
A modern hotel with a prominent glass facade, palm trees, and a clear sky.

4. H2O Suites - Adults Only

H2O Suites - Adults Only
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
United States
Carmen
AU$661
includes taxes & fees
2 Nov - 3 Nov
H2O Suites - Adults Only
A pool area with lounge chairs and a table, surrounded by palm trees.
A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.
A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.
A building with a neon sign that reads "Orchid Key Inn."

5. Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
United States
ben
AU$411
includes taxes & fees
27 Oct - 28 Oct
Orchid Key Inn - Adults Only
A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.
A bar area with a counter, chairs, and a clock.
A colonial-style building with a porch, surrounded by lush tropical vegetation.
A couple walking along a poolside pathway surrounded by lush greenery.

6. The Gardens Hotel

The Gardens Hotel
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Gisele
AU$544
includes taxes & fees
15 Oct - 16 Oct
The Gardens Hotel
A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.
A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.
A narrow room with a bed, a potted plant, and a window with blinds.
A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

7. Alexander's Guesthouse - Adult Exclusive

Alexander's Guesthouse - Adult Exclusive
Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary
AU$422
includes taxes & fees
15 Oct - 16 Oct
Alexander's Guesthouse - Adult Exclusive
A porch with a white railing, a bench, and a flag.
A living room with a sofa, a glass coffee table, a TV, and a painting on the wall.
A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.
A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.

8. The Conch House Heritage Inn

The Conch House Heritage Inn
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
United States
John
AU$460
includes taxes & fees
25 Oct - 26 Oct
The Conch House Heritage Inn
A gated entrance to Villas Key West with a brick pathway leading to the gate.
A covered entrance with a brick pathway leading to a gated area, surrounded by lush greenery and plants.
A covered porch with wicker furniture, a large potted plant, and a sign for Villas Key West.
A swimming pool with a hot tub, surrounded by a wooden deck and lush greenery.

9. Key West Villas

Key West Villas
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Margaret
AU$421
includes taxes & fees
15 Oct - 16 Oct
Key West Villas
A two-story house with a covered porch, a brick pathway, and a large tree.
A covered porch with white wicker furniture and a blue floor, surrounded by lush tropical plants.
A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.
A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

10. The Marquesa Hotel

The Marquesa Hotel
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
United States
Anna
AU$659
includes taxes & fees
15 Oct - 16 Oct
The Marquesa Hotel
A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.
A covered walkway with a wooden ceiling, white railings, and a brick path.
A garden with a pond, rocks, and various plants.
A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

11. Island City House Hotel

Island City House Hotel
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
United States
Osvaldo
AU$284
includes taxes & fees
15 Oct - 16 Oct
Island City House Hotel
A pool area with lounge chairs and palm trees.
A neatly made bed with patterned pillows, a bedside table with a bottle and glasses, and a window with orchids.
A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.
A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

12. Santa Maria Suites

Santa Maria Suites
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
United States
Anthony
AU$578
includes taxes & fees
27 Oct - 28 Oct
Santa Maria Suites
A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.
A bedroom with a bed, nightstand, lamp, air conditioning unit, and a no smoking sign.
A covered outdoor area with a wooden staircase, seating, and potted plants.
A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.

13. The Grand Guesthouse

The Grand Guesthouse
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
United States
Justyn
AU$274
includes taxes & fees
15 Oct - 16 Oct
The Grand Guesthouse
A room with a bed, a ceiling fan, and a window with blinds.
A room with a yellow armchair, a glass coffee table, and a view of a wooden deck and tropical plants.
A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.
A poolside area with lounge chairs, a covered seating area, and a small pool.

14. The Mermaid & Alligator

The Mermaid & Alligator
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
United Kingdom
Adam
AU$372
includes taxes & fees
15 Oct - 16 Oct
The Mermaid & Alligator
A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.
A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.
A bedroom with a bed, two bedside lamps, a ceiling fan, and a view of a balcony with plants.
A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

15. Westwinds Inn

Westwinds Inn
Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary
United States
Anthony
AU$261
includes taxes & fees
25 Oct - 26 Oct
Westwinds Inn
A swimming pool with water splashing, surrounded by palm trees and a building in the background.
The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.
A hotel with a pool, bicycles, and lush greenery.
The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

16. Silver Palms Inn & Historic Homes

Silver Palms Inn & Historic Homes
Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary
United States
sam
AU$240
includes taxes & fees
25 Oct - 26 Oct
Silver Palms Inn & Historic Homes
A large, ornate hotel with a pool, palm trees, and a view of the ocean.
A grand staircase with ornate railings and a chandelier.
A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.
A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

17. Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive
Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary
United States
Amy
AU$407
includes taxes & fees
28 Oct - 29 Oct
Southernmost House - Adult Exclusive
A green house with a white porch, a flag, and a sign advertising a property for sale.
A covered porch with wicker furniture, potted plants, and a view of the house.
A bedroom with a large bed, a sofa, a nightstand, and a painting on the wall.
A bathroom with a vanity, a mirror, and a window with blinds.

18. L'Habitation Guest House - Adults Only

L'Habitation Guest House - Adults Only
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
United States
Richard
AU$275
includes taxes & fees
28 Oct - 29 Oct
L'Habitation Guest House - Adults Only
A poolside area with lounge chairs, umbrellas, and a pergola.
An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.
A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.
A living room with a spiral staircase, a sofa, a chair, a coffee table, and a view of an outdoor seating area.

19. Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
Henry
AU$475
includes taxes & fees
15 Oct - 16 Oct
Ella's Cottages - Key West Historic Inns
A gated entrance with lush green foliage and a white picket fence.
A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.
A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.
A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

20. Coco Plum Inn

Coco Plum Inn
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
United States
Riley
AU$290
includes taxes & fees
15 Oct - 16 Oct
Coco Plum Inn
View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.
Almond Tree Inn Hotel - Adults Only
10.0
Exceptional
1,004 reviews
View
A tropical outdoor area with palm trees, hanging plants, and string lights.
Douglas House - Adults Only
9.8
Exceptional
555 reviews
View
A modern interior with a staircase, a sofa set, a wooden table, and a television.
Simonton Court Historic Inn & Cottages
9.8
Exceptional
1,006 reviews
View
A modern outdoor area with a pool, lounge chairs, and a bar area.
H2O Suites - Adults Only
9.8
Exceptional
666 reviews
View
A pool area with lounge chairs and a table, surrounded by palm trees.
Orchid Key Inn - Adults Only
9.8
Exceptional
1,003 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent
"The beach was not swimma"
Kamila 4-night trip
Posted 1 hour ago
Casa Marina Key West, Curio Collection by Hilton
Paradise Inn Key West - Adults Only

Paradise Inn Key West - Adults Only

10/10 Excellent
"Place was great, clean, and reasonable. Beware the roosters at 6am but that might be the entire city of Key West Old Town"
Jason 2-night trip
Posted 3 hours ago
Paradise Inn Key West - Adults Only
Duval House

Duval House

10/10 Excellent
"Na"
Catherine A 3-night trip
Posted 4 hours ago
Duval House
Southwinds Motel

Southwinds Motel

10/10 Excellent
"The staff was very professional."
Antonia 1-night trip
Posted 6 hours ago
Southwinds Motel
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

10/10 Excellent
"The resort was excellent. It was clean. The staff were very accommodating. The breakfast & dinners we had a The beach side Cafe were very good. The bars closed rather early on the resort by 9pm. We felt that one bar on the resort should open until 11pm to accommodate guests that want stay at the resort in the evening. Also a shuttle to and from the airport should be offered."
JoAnn 5-night trip
Posted 7 hours ago
Southernmost Beach Resort and Guesthouses
The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only

10/10 Excellent
"Everything was perfect. Nice breakfast, immaculate pool. Very clean room and property grounds. On issue was that the hot tub was like warm -not hot."
ANTHONY 4-night trip
Posted 14 hours ago
The Cabana Inn Key West - Adults Only
Wicker Guesthouse

Wicker Guesthouse

10/10 Excellent
"The staff were very helpful and friendly. Would highly recommend the guest house."
Judy 2-night trip
Posted 2 days ago
Wicker Guesthouse
Douglas House - Adults Only

Douglas House - Adults Only

10/10 Excellent
"Loved our little private porch however the construction next door made it unbearable. Not the fault of the property. The room was spacious and the location was wonderful. The pool is well maintained and a nice oasis after a hot, busy day. Be aware parking is around the corner and very expensive. It cost us $100 for 3 days. The staff was friendly Overall an enjoyable stay and I would sty here again"
Judy 3-night trip
Posted 2 days ago
Douglas House - Adults Only
Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West

10/10 Excellent
"Great location. Walking distance to Anything you’d want to do in Key West. Housekeeping staff very attentive. Valets very friendly and quick to attend. Room was clean spacious and bed comfortable. Restaurant was just OK. Staff there not as friendly and attentive. Pool was ok."
Amy 3-night trip
Posted 2 days ago
Opal Key Resort & Marina, Key West

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
See properties
A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
See properties
A wooden signpost with directional arrows pointing to various cities and their distances.
Photo by Martin Pettersson

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.
See properties
The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)
You can learn about the history of Key West with a trip to Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.
See properties

Coffee Butler Amphitheater

You can make plans for a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.
See properties

USCGC Ingham Maritime Museum

You can spend an afternoon browsing the exhibits at USCGC Ingham Maritime Museum during your trip to Key West.
See properties

Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.
See properties

We Cycle Key West

You can do some window-shopping at We Cycle Key West during your stay in Key West.
See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1487 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveller data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1487 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater and Key West Film Society if you're interested in local theatre.