Top Hotels Near Florida Keys National Marine Sanctuary in Key West from AU$231

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Accommodation near Florida Keys National Marine Sanctuary

Queen Deluxe ADA
Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only

3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1000)
"Great place to stay. "
United States
Bettina
The price is AU$409
includes taxes & fees
10 Dec - 11 Dec
Almond Tree Inn Hotel - Adults Only
Exterior
Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only

3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1000)
"Great location and amazing staff!"
United States
Charles
The price is AU$403
includes taxes & fees
10 Dec - 11 Dec
Orchid Key Inn - Adults Only
Carriage House | Terrace/patio
The Gardens Hotel

The Gardens Hotel

4.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1000)
"Amazing hotel, the perfect Key West vibe. Clean rooms, delicious breakfast. We will come back again"
United States
Isis
The price is AU$551
includes taxes & fees
9 Dec - 10 Dec
The Gardens Hotel
King Room D | Balcony
Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages

2.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (876)
"The staff was really nice"
United States
doug
The price is AU$303
includes taxes & fees
8 Dec - 9 Dec
Simonton Court Historic Inn & Cottages
Outdoor pool, pool loungers
The Conch House Heritage Inn

The Conch House Heritage Inn

3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (144)
"Fantastic location "
United States
ANDREW
The price is AU$326
includes taxes & fees
9 Dec - 10 Dec
The Conch House Heritage Inn
Exterior
The Marquesa Hotel

The Marquesa Hotel

3.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1000)
"Perfect place to stay. "
United States
Paulette
The price is AU$676
includes taxes & fees
9 Dec - 10 Dec
The Marquesa Hotel
Deluxe Suite, 1 King Bed, Private Pool | View from room
H2O Suites - Adults Only

H2O Suites - Adults Only

3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (580)
"Great place!!"
United States
Joel
The price is AU$608
includes taxes & fees
16 Dec - 17 Dec
H2O Suites - Adults Only
Outdoor pool, pool loungers
The Mermaid & Alligator

The Mermaid & Alligator

3.5 star property
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (270)
"Property had several areas to relax."
United States
Mateo
The Mermaid & Alligator
Signature Apartment, 1 Bedroom, Kitchen, Poolside (Room 17) | Terrace/patio
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

3.5 star property
Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (129)
"Great place to stay always clean an the employees are very respectful "
United States
Charles
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
Garden
Douglas House

Douglas House

3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (218)
"Very clean room, loved the location!"
United States
Jeffrey Ray
The price is AU$255
includes taxes & fees
17 Dec - 18 Dec
Douglas House
Exterior
Coco Plum Inn

Coco Plum Inn

3.0 star property
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (461)
"Overall great for couple's stay. "
United States
Quazi
The price is AU$314
includes taxes & fees
15 Dec - 16 Dec
Coco Plum Inn
11 Gecko's Garden - Adults Only
Tropical Inn

Tropical Inn

3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (363)
"The place was excellent and the service amazing "
United States
Janae
The price is AU$408
includes taxes & fees
8 Dec - 9 Dec
Tropical Inn
Fountain
Island City House Hotel

Island City House Hotel

3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1000)
"This is the best place to stay near all the waterfront spots but still in the neighborhoods. Nice pool, ice, washer/dryer, great staff - it is so warm n friendly! Would stay again and again!"
United States
Gregory
The price is AU$298
includes taxes & fees
15 Dec - 16 Dec
Island City House Hotel
Exterior
The Grand Guesthouse

The Grand Guesthouse

2.5 star property
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1001)
"Great stay"
United States
Ginger
The Grand Guesthouse
Premium bedding, iron/ironing board, free WiFi, bed sheets
Weatherstation Inn

Weatherstation Inn

2.5 star property
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (991)
"Wonderful property safe neighborhood convenient to all activities would stay here again."
United States
William
The price is AU$334
includes taxes & fees
16 Dec - 17 Dec
Weatherstation Inn
Front of property
L'Habitation Guest House

L'Habitation Guest House

2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (919)
"Great place close to all. Manager was very helpful in recommending how to get around the island, what to do and where to eat."
United States
Robert
The price is AU$231
includes taxes & fees
8 Dec - 9 Dec
L'Habitation Guest House
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers
Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns

3.5 star property
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (401)
"Friendly staff, Beautiful property "
United States
Ishta
The price is AU$430
includes taxes & fees
15 Dec - 16 Dec
Ella's Cottages - Key West Historic Inns
3 outdoor pools, a heated pool, pool loungers
Ambrosia Key West

Ambrosia Key West

3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1002)
"Great breakfast options, quiet, clean. Walkable where we wanted to go"
United States
Alma D
The price is AU$416
includes taxes & fees
8 Dec - 9 Dec
Ambrosia Key West
Outdoor pool, pool umbrellas, pool loungers
Marrero's Guest Mansion

Marrero's Guest Mansion

3.5 star property
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (335)
"Location very good Staff friendly Pool not well maintained Breakfast and happy hour lacking compared to others"
United States
Scott
The price is AU$551
includes taxes & fees
7 Jan - 8 Jan 2026
Marrero's Guest Mansion
Outdoor pool
Silver Palms Inn

Silver Palms Inn

3.5 star property
Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1008)
"We had a wonderful stay and it was a convenient location for all the activities along Duval Street. The room was clean & comfortable with a great breakfast."
United States
Susanne
The price is AU$283
includes taxes & fees
14 Dec - 15 Dec
Silver Palms Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Florida Keys National Marine Sanctuary Hotel Reviews

Lighthouse Hotel - Key West Historic Inns

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent
"Clean inside and out! Staff extremely helpful and friendly. Grounds were pristine. About 10 reaident chickens but thwy behaves. Pool very refreshing and outside tables located in tranquil location. Would certainly stay again."
Cynthia 4-night trip
Posted 1 day ago
Lighthouse Hotel - Key West Historic Inns

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center which includes interior views

Florida Keys Eco - Discovery Center

4.3/5 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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Fort Zachary Taylor Park, Key West. State Park in Florida, USA., Shutterstock ID 761867707, Purchase Order: SP-1891 Wave 0, Client/Licensee: Hotels.com

Fort Zachary Taylor Historic State Park

4.4/5 (1,160 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1564 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Southernmost Beach Resort and Guesthouses is one of the top choices for your stay based on our traveller data, and this hotel offers 3 outdoor pools and a full-service spa. It's located just a short 0.7 mi (1.1 km) from Florida Keys National Marine Sanctuary. Other good choices close by include La Concha Key West, Autograph Collection and Winslow's Bungalows - Key West Historic Inns.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1564 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse and Key West Film Society if you're interested in local theatre.