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Our top choices for Effingham hotels

Holiday Inn Express & Suites Latta by IHG

Holiday Inn Express & Suites Latta by IHG
2.5 star property
Latta
9.6 out of 10, Exceptional, (536)
"The staff was great and the room was very clean"
United States
Mark Whitehurst
The price is AU$182
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Latta by IHG

Quality Inn Mullins - Marion

Quality Inn Mullins - Marion
2.5 star property
Marion
7.8 out of 10, Good, (378)
"It was ok clean would stay there again. "
United States
jeff
The price is AU$161
includes taxes & fees
7 Jan - 8 Jan 2026
Quality Inn Mullins - Marion

Best Western Executive Inn

Best Western Executive Inn
2.5 star property
Latta
8.2 out of 10, Very good, (939)
"Would definitely stay again !!!"
United States
Tracy
The price is AU$124
includes taxes & fees
24 Jan - 25 Jan 2026
Best Western Executive Inn

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC
2.5 star property
Florence
9.0 out of 10, Wonderful, (2217)
"Clean room and friendly staff!"
United States
Daria
The price is AU$141
includes taxes & fees
4 Jan - 5 Jan 2026
Park Inn by Radisson Florence, SC

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area
2.5 star property
Florence
9.2 out of 10, Wonderful, (1180)
"Great location, friendly staff. "
United States
Defelicio
The price is AU$164
includes taxes & fees
18 Jan - 19 Jan 2026
Comfort Inn & Suites Florence Center Area

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence
2.0 star property
Florence
8.6 out of 10, Excellent, (2528)
"Great room and staff."
United States
LEE
The price is AU$105
includes taxes & fees
31 Dec - 1 Jan 2026
Howard Johnson by Wyndham Florence

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown
3.0 star property
Florence
9.0 out of 10, Wonderful, (1006)
"Great experience in a nice hotel in downtown."
United States
HATIM
The price is AU$167
includes taxes & fees
19 Jan - 20 Jan 2026
Hyatt Place Florence Downtown

Tru by Hilton Florence I-95

Tru by Hilton Florence I-95
2.5 star property
Florence
8.4 out of 10, Very good, (1002)
"We enjoyed our stay. Everything stood out Staff, Clean room and Amenities. "
United States
Marita
The price is AU$161
includes taxes & fees
6 Jan - 7 Jan 2026
Tru by Hilton Florence I-95

Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95
2.5 star property
Florence
9.0 out of 10, Wonderful, (826)
"Overall great experience!! Staff was very nice, hotel was very clean & such a plus that it’s dog friendly. "
United States
Paul
The price is AU$191
includes taxes & fees
9 Jan - 10 Jan 2026
Hampton Inn & Suites Florence-North-I-95

Fairfield Inn & Suites by Marriott Florence I-20

Fairfield Inn & Suites by Marriott Florence I-20
2.5 star property
Florence
9.0 out of 10, Wonderful, (562)
"Clean room, professional and courteous staff. "
United States
Felicia
The price is AU$183
includes taxes & fees
7 Jan - 8 Jan 2026
Fairfield Inn & Suites by Marriott Florence I-20

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
2.5 star property
Florence
8.6 out of 10, Excellent, (1007)
"Friendly staff, quick check in, nice lobby"
United States
Jennifer
The price is AU$190
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence
3.0 star property
Florence
8.0 out of 10, Very good, (1676)
"Staff was great, breakfast was well stocked "
United States
constance
The price is AU$156
includes taxes & fees
15 Jan - 16 Jan 2026
La Quinta Inn & Suites by Wyndham Florence

Best Western Inn

Best Western Inn
2.5 star property
Florence
7.6 out of 10, Good, (1004)
"very clean and quiet"
United States
Marissa
The price is AU$148
includes taxes & fees
31 Dec - 1 Jan 2026
Best Western Inn

Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC
2.5 star property
Florence
8.0 out of 10, Very good, (32)
"Friendly staff and clean environment "
United States
john
The price is AU$169
includes taxes & fees
5 Jan - 6 Jan 2026
Spark by Hilton Florence North I-95, SC

Comfort Suites Florence I-95

Comfort Suites Florence I-95
2.5 star property
Florence
8.4 out of 10, Very good, (1003)
"Pool was clean good breakfast "
United States
Ann
The price is AU$177
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Suites Florence I-95

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center
2.5 star property
Florence
7.8 out of 10, Good, (1262)
"Room was spotless and the staff was friendly..."
United States
Randy
The price is AU$132
includes taxes & fees
28 Jan - 29 Jan 2026
Quality Inn & Suites Florence Civic Center

Residence Inn Marriott Florence

Residence Inn Marriott Florence
3.0 star property
Florence
8.8 out of 10, Excellent, (489)
"Yes our stay was great big variety on breakfast clean hotel rooms nice to have a kitchen had a great day"
United States
Marialinda
The price is AU$165
includes taxes & fees
4 Jan - 5 Jan 2026
Residence Inn Marriott Florence

The Inn at the Crossroads

The Inn at the Crossroads
2.0 star property
Lake City
9.4 out of 10, Exceptional, (834)
"The place itself is adorable! The rooms were very clean, great size and large bathroom which was a plus with 4 in a room. "
United States
Angela
The price is AU$212
includes taxes & fees
31 Dec - 1 Jan 2026
The Inn at the Crossroads

Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center
2.5 star property
Florence
9.0 out of 10, Wonderful, (827)
"My go to stay while in Fairfax. "
United States
Gregory
The price is AU$163
includes taxes & fees
25 Jan - 26 Jan 2026
Hampton Inn & Suites Florence Center

Super 8 by Wyndham Florence

Super 8 by Wyndham Florence
2.0 star property
Florence
7.0 out of 10, Good, (1002)
"Perfect overnight spot"
United States
Martin
The price is AU$96
includes taxes & fees
6 Jan - 7 Jan 2026
Super 8 by Wyndham Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Effingham Hotel Reviews

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Frequently asked questions

Where is the best place to stay in Effingham?
Howard Johnson by Wyndham Florence, located 12.3 mi (19.8 km) from the heart of Effingham, is a top choice for your stay, based on our traveller data. Other good options for your trip to the area are Park Inn by Radisson Florence, SC and Comfort Inn & Suites Florence Center Area. See all available top hotels, or vacation rentals in Effingham.
What are some of the best holiday rentals that Effingham has to offer?
Perfect Stop • Near I-95, Downtown & Civic Center and Darlington: This holiday home rental outside of Effingham offers a fireplace, 1 hot tub and air conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a stovetop and a microwave. See all vacation rentals in Effingham.
If I need to cancel my hotel reservation in Effingham, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Effingham.
What's it like to stay in Effingham?
Travellers to Effingham will find plenty to explore and enjoy. There are 133 hotels and other accommodation options in the surrounding area. Find out more about Effingham.
What should I see while I'm in Effingham?
A favourite place to visit is Lynches River State Park. You'll also find Florence National Cemetery and Florence Museum in the area. Take a look at what more there is to see and do in Expedia's Effingham guide.
What's the seasonal weather in Effingham?
The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 10°C. Average annual precipitation for Effingham is 1366 mm.

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