Top Hotels Near Edisto Island Serpentarium in Edisto Island from AU$493

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15 Dec - 16 Dec
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16 Dec - 17 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Edisto Island Serpentarium hotels

Lounge
Charleston Kiawah Island/Andell Inn

Charleston Kiawah Island/Andell Inn

Charleston Kiawah Island/Andell Inn
3.5 star property
13.4 km from Edisto Island Serpentarium
9.6 out of 10, Exceptional, (518)
"Spotless room, friendly staff, amazing breakfast, great access to shopping and restaurants were all the things that made our stay wonderful! We want to return!"
United States
John
The price is AU$534
includes taxes & fees
4 Jan - 5 Jan 2026
Charleston Kiawah Island/Andell Inn
Bar (on property)
The Dunlin, Auberge Collection

The Dunlin, Auberge Collection

The Dunlin, Auberge Collection
5.0 star property
16.4 km from Edisto Island Serpentarium
9.8 out of 10, Exceptional, (31)
"Beautiful hotel, had a perfect stay!"
United States
Madison
The Dunlin, Auberge Collection
Children’s play area – outdoor
The Sanctuary at Kiawah Island Golf Resort

The Sanctuary at Kiawah Island Golf Resort

The Sanctuary at Kiawah Island Golf Resort
5.0 star property
18.3 km from Edisto Island Serpentarium
9.6 out of 10, Exceptional, (228)
"all was excellent."
United States
michael
The price is AU$493
includes taxes & fees
17 Dec - 18 Dec
The Sanctuary at Kiawah Island Golf Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Edisto Island Serpentarium Hotel Reviews

Seaclusion by AvantStay | Walk to the Beach

Seaclusion by AvantStay | Walk to the Beach

10/10 Excellent
"Amenities were great, customer service was excellent"
April B. 7-night trip
Posted 2 weeks ago
Seaclusion by AvantStay | Walk to the Beach

Hotels near other Edisto Island Serpentarium attractions

Botany Bay Plantation

4.3/5 (13 reviews)
Explore the great outdoors at Botany Bay Plantation, a lovely green space in Edisto Island. Stroll along the beaches in this relaxing area or seek out the fishing spots.
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With These Hands Gallery

You can spend time studying the exhibits at With These Hands Gallery during your travels in Edisto Island. Stroll along the beautiful beaches in this relaxing area or seek out the cycling trails.
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Frequently asked questions

What's the area like around Edisto Island Serpentarium?
Edisto Island Serpentarium is located in an area of Edisto Island known for its beautiful beaches. You'll find 190 hotels and other accommodations within a few miles for a convenient home base.
How many hotels are there near Edisto Island Serpentarium?
Expedia has 190 hotels and other accommodation options a few miles from Edisto Island Serpentarium.
If I need to cancel the hotel reservation for my stay near Edisto Island Serpentarium, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and receive a refund within 24 hours of booking. Enter your dates, click on "Search", then filter by "fully refundable" to get the best deals available near Edisto Island Serpentarium.
What can I see and do near Edisto Island Serpentarium?
Attractions like With These Hands Gallery and Edisto Island Museum highlight the local culture. You might plan a visit to Edisto Beach State Park or Botany Bay Plantation Heritage Preserve and Wildlife Management Area while you're in the area. You might also stop by Bohicket Marina, located 7.9 mi from Edisto Island Serpentarium, or Freshfields Village which is 8.3 mi away.