A tree-lined landscape with a river and fields.

Search East Prairie hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
24 July - 26 July
Next weekend
31 July - 2 Aug

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for East Prairie hotels

Indoor pool, outdoor pool

1. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,007 reviews)
"Nice hotel with evening dinner and buffet breakfast."
United States
Sally
The price is AU$182
includes taxes & fees
26 July - 27 July
Drury Inn & Suites Sikeston, MO
Exterior

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (483 reviews)
"Nice!"
United States
theresa
The price is AU$148
includes taxes & fees
9 Aug - 10 Aug
Holiday Inn Express & Suites Sikeston Southwest by IHG
Exterior

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (421 reviews)
"Staff was excellent. It was fine for what it was ā€” a cheap place near the highway"
United States
Emily
The price is AU$113
includes taxes & fees
27 July - 28 July
The Riverstone Hotel Charleston-Sikeston
Exterior

4. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (593 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
United States
Brandi
The price is AU$171
includes taxes & fees
14 Aug - 15 Aug
Hampton Inn Sikeston
Property amenity

5. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (100 reviews)
"Perfect last minute stop on our road trip Very clean, well maintained and pleasant staff"
United States
Dwain
The price is AU$178
includes taxes & fees
9 Aug - 10 Aug
Fairfield Inn & Suites by Marriott Sikeston
Free daily full breakfast

6. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,001 reviews)
"Old but well maintained for quick overnight stay"
United States
Carl
The price is AU$151
includes taxes & fees
4 Aug - 5 Aug
Best Western Plus Sikeston I-55
Desk, blackout curtains, iron/ironing board (on request), free WiFi

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (802 reviews)
"I love it there."
United States
Sharika West
The price is AU$105
includes taxes & fees
29 July - 30 July
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

8. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (648 reviews)
"Clean rooms,"
United States
Karl
The price is AU$94
includes taxes & fees
26 July - 27 July
Super 8 by Wyndham Charleston/Sikeston East MO
Property amenity

9. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is AU$201
includes taxes & fees
16 Aug - 17 Aug
TownePlace Suites by Marriott Sikeston
Exterior

10. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (300 reviews)
"Hotel was nice an clean. Friendly staff. Clean hotel rooms and free breakfast every morning."
United States
Starlette
The price is AU$149
includes taxes & fees
11 Aug - 12 Aug
Comfort Inn & Suites Sikeston I-55
Iron/ironing board (on request), free WiFi, bed sheets

11. Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (144 reviews)
"Enjoyed our stay. All the appliances worked and our air conditioner kept us cool! Will definitely stay here again!"
United States
Sheryl
The price is AU$95
includes taxes & fees
25 July - 26 July
Country Yard Inn and Suite
Room, 1 Queen Bed, Non Smoking

12. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (69 reviews)
"Clean room, The receptionist very friendly, good parking."
United States
Temera
The price is AU$121
includes taxes & fees
22 July - 23 July
Super 8 By Wyndham Marston
Room, 1 King Bed, Non Smoking | View from room

13. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is AU$110
includes taxes & fees
1 Aug - 2 Aug
Eagle Inn Charleston
Lobby

14. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (291 reviews)
"Breakfast was sparse. This motel needs a complete overhaul. "
United States
Susan
The price is AU$103
includes taxes & fees
7 Aug - 8 Aug
Quality Inn Cairo I-57
Free buffet breakfast

15. Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very good, (533 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is AU$120
includes taxes & fees
12 Aug - 13 Aug
Quality Inn Union City US 51
Lobby

16. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (415 reviews)
"The room was clean, the breakfast was good. We enjoyed our stay."
United States
David
The price is AU$143
includes taxes & fees
11 Aug - 12 Aug
Sleep Inn at Discovery Park of America
Premier Room, 1 Bedroom, Non Smoking

17. New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (789 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is AU$84
includes taxes & fees
26 July - 27 July
New Orleans Inn Portageville
Free WiFi, bed sheets

18. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
2.5 star property
Marston
6.0 out of 10, (126 reviews)
"OLD FACILITY, NEED TO FIX SOMETHINGS."
United States
Bosup
The price is AU$107
includes taxes & fees
22 July - 23 July
Travel Inn Marston I-55 by Hotel O
Exterior

19. Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (337 reviews)
"Everything was to my liking"
United States
Faye
The price is AU$170
includes taxes & fees
2 Aug - 3 Aug
Holiday Inn Express & Suites Union City by IHG
Terrace/patio

20. Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (190 reviews)
"Friendly staff, comfortable bed."
United States
James
The price is AU$167
includes taxes & fees
2 Aug - 3 Aug
Hampton Inn Union City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

10/10 Excellent
"Everything was nice."
Richard 1-night trip
Posted 1 day ago
Sleep Inn at Discovery Park of America

More cheap accommodation in East Prairie

New Orleans Inn Portageville

New Orleans Inn Portageville

600 US-61 Portageville MO
The price is AU$84 per night from 26 July to 27 July
AU$84
26 July - 27 July
includes taxes & fees
8/10 Very good! (789 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Best Western Plus Sikeston I-55 and Days Inn and Suites by Wyndham Sikeston. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 36 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Mississippi River and Big Oak Tree State Park exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25Ā°C, while the coldest months are January and February, with an average of 5Ā°C. Average annual precipitation for East Prairie is 1522 mm.