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5 Dec - 6 Dec
Tomorrow
6 Dec - 7 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

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Top hotels and accommodation in East Prairie

1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 star property
Sikeston
7.2 out of 10, Good, (1001)
"The beds were comfortable and clean"
United States
Heather
Travelling for leisure
The price is AU$109
includes taxes & fees
9 Dec - 10 Dec
Days Inn and Suites by Wyndham Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (439)
"Friendly staff, comfortable beds, spacious room (313)."
United States
Julie
Travelling for leisure
The price is AU$163
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Friendly staff, clean room, easy in and out."
United States
Christopher
The price is AU$159
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express & Suites Sikeston Southwest by IHG
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 star property
Sikeston
8.4 out of 10, Very good, (1003)
"The bed was clean and comfortable"
United States
Whitney
Travelling with family
The price is AU$138
includes taxes & fees
14 Dec - 15 Dec
Best Western Plus Sikeston
Front of property – evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
Charleston
6.6 out of 10, (611)
"Located very close to the expanse of corn fields, quiet, clean rooms"
United States
Yan Robby
Travelling for business
The price is AU$99
includes taxes & fees
3 Jan - 4 Jan 2026
Super 8 by Wyndham Charleston/Sikeston East MO
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 star property
Union City
9.2 out of 10, Wonderful, (313)
"Loved the shower with glass doors."
United States
Terra
Travelling for leisure
The price is AU$145
includes taxes & fees
28 Dec - 29 Dec
Sleep Inn at Discovery Park of America
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very good, (715)
"the towels and linens were clean and fresh smelling"
United States
Roger
Travelling with partner
The price is AU$95
includes taxes & fees
7 Dec - 8 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"This hotel is very comfortable clean"
United States
Kimberly
Travelling for business
The price is AU$130
includes taxes & fees
14 Dec - 15 Dec
Pear Tree Inn Sikeston
Seasonal outdoor pool
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

2.5 star property
Union City
6.8 out of 10, (365)
"The room was spotless, well-stocked with essentials, and surprisingly quiet."
United States
Edwin
Travelling for leisure
The price is AU$98
includes taxes & fees
3 Jan - 4 Jan 2026
Hospitality House Union City I 69 / US 51
Room, 1 King Bed, Accessible, Non Smoking
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
Sikeston
6.6 out of 10, (561)
"Good food around area and bed was comfort"
United States
Derrick
Travelling with friends
The price is AU$100
includes taxes & fees
7 Dec - 8 Dec
Super 8 by Wyndham Sikeston/Miner Area
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Pool was clean and looked nice."
United States
Leslie
Travelling for leisure and business
The price is AU$157
includes taxes & fees
9 Dec - 10 Dec
Drury Inn & Suites Sikeston, MO
Lobby
Quality Inn Union City US 51

Quality Inn Union City US 51

2.5 star property
Union City
8.4 out of 10, Very good, (483)
"Pool, entertainment for children, nice restaurant close, breakfast good."
United States
Shirley
Travelling for business
The price is AU$121
includes taxes & fees
28 Dec - 29 Dec
Quality Inn Union City US 51
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

2.5 star property
Sikeston
8.4 out of 10, Very good, (280)
"hotel was fine clean and convient"
United States
Denise
Travelling solo
The price is AU$145
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn & Suites Sikeston I-55
Bar (on property)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (38)
"Very clean and comfortable room."
United States
Roxanne
Travelling solo
The price is AU$173
includes taxes & fees
12 Dec - 13 Dec
Fairfield Inn & Suites by Marriott Sikeston
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

2.5 star property
Union City
9.6 out of 10, Exceptional, (162)
"Very clean nice quiet rooms"
United States
april
Travelling for leisure
The price is AU$157
includes taxes & fees
26 Dec - 27 Dec
Hampton Inn Union City
Bar (on property)
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3.0 star property
Sikeston
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is AU$202
includes taxes & fees
14 Dec - 15 Dec
TownePlace Suites by Marriott Sikeston
Reception
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

2.5 star property
Union City
8.6 out of 10, Excellent, (547)
"Clean rooms, helpful and polite staff"
United States
Jennifer
Travelling with partner
The price is AU$129
includes taxes & fees
6 Dec - 7 Dec
Country Hearth Inn & Suites Union City
Premier Room, 1 Bedroom, Non Smoking
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 star property
Portageville
8.0 out of 10, Very good, (724)
"Room was clean and comfortable"
United States
Twila
Travelling for leisure
New Orleans Inn Portageville
Free daily buffet breakfast
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

2.5 star property
Union City
9.4 out of 10, Exceptional, (308)
"The room was very clean."
United States
dena
Travelling with partner
The price is AU$180
includes taxes & fees
20 Dec - 21 Dec
Holiday Inn Express & Suites Union City by IHG
Exterior
Super 8 By Wyndham Marston

Super 8 By Wyndham Marston

2.0 star property
Marston
7.8 out of 10, Good, (37)
"Todo excelente "
Mexico
Lirra Diaz
The price is AU$91
includes taxes & fees
11 Dec - 12 Dec
Super 8 By Wyndham Marston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

New Orleans Inn Portageville

New Orleans Inn Portageville

10/10 Excellent
"Clean, comfortable, quiet and affordable. Would recommend this place to anyone passing through Portageville."
Hannah 1-night trip
Posted 3 days ago
New Orleans Inn Portageville

More cheap accommodation in East Prairie

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
The price is AU$109 per night from 9 Dec to 10 Dec
AU$109
9 Dec - 10 Dec
includes taxes & fees
7.2/10 Good! (1,000 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Days Inn and Suites by Wyndham Sikeston and Hampton Inn Sikeston. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find New Madrid Historical Museum and Columbus-Belmont State Park in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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