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Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,005 reviews)
"As always it was a perfect visit"
United States
John
The price is AU$161
includes taxes & fees
18 Feb - 19 Feb
Drury Inn & Suites Sikeston, MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (620 reviews)
"Staff was great! Room was nice. "
United States
Lana
The price is AU$103
includes taxes & fees
18 Feb - 19 Feb
Super 8 by Wyndham Charleston/Sikeston East MO

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (332 reviews)
"The rooms are big and the property is spotless!"
United States
debbie
The price is AU$152
includes taxes & fees
1 Feb - 2 Feb
Sleep Inn at Discovery Park of America

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (463 reviews)
"Very clean and super friendly staff!"
United States
Katherine
The price is AU$173
includes taxes & fees
1 Feb - 2 Feb
Hampton Inn Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,004 reviews)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is AU$122
includes taxes & fees
25 Jan - 26 Jan
Best Western Plus Sikeston

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.2 out of 10, Wonderful, (312 reviews)
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is AU$169
includes taxes & fees
6 Feb - 7 Feb
Holiday Inn Express & Suites Union City by IHG

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (374 reviews)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is AU$97
includes taxes & fees
17 Feb - 18 Feb
Hospitality House Union City I 69 / US 51

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (491 reviews)
"Nice room"
Mexico
José Ricardo
The price is AU$119
includes taxes & fees
8 Feb - 9 Feb
Quality Inn Union City US 51

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (551 reviews)
"Roaches!"
United States
Teresa
The price is AU$91
includes taxes & fees
1 Feb - 2 Feb
Country Hearth Inn & Suites Union City

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,004 reviews)
"Everything was excellent"
United States
James
The price is AU$107
includes taxes & fees
25 Jan - 26 Jan
Days Inn and Suites by Wyndham Sikeston

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (284 reviews)
"The hotel was very clean, beds were comfortable, and staff was friendly and helpful."
United States
aileen
The price is AU$144
includes taxes & fees
24 Jan - 25 Jan
Comfort Inn & Suites Sikeston I-55

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (584 reviews)
"Great place"
United States
Misty
The price is AU$101
includes taxes & fees
19 Feb - 20 Feb
Super 8 by Wyndham Sikeston/Miner Area

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (43 reviews)
"Great hotel, great staff"
United States
Dmitry
The price is AU$95
includes taxes & fees
21 Jan - 22 Jan
Super 8 By Wyndham Marston

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (168 reviews)
"Staff was great. Room was ready and clean. "
United States
Robert
The price is AU$197
includes taxes & fees
1 Feb - 2 Feb
Hampton Inn Union City

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.2 out of 10, Wonderful, (50 reviews)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is AU$171
includes taxes & fees
29 Jan - 30 Jan
Fairfield Inn & Suites by Marriott Sikeston

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (446 reviews)
"Stay was excellent "
United States
Kourtney
The price is AU$158
includes taxes & fees
8 Feb - 9 Feb
Holiday Inn Express & Suites Sikeston Southwest by IHG

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (734 reviews)
"Parking was good, staff was great "
United States
Corey
New Orleans Inn Portageville

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (731 reviews)
"Clean room and easy access to room"
United States
Anne
The price is AU$99
includes taxes & fees
18 Feb - 19 Feb
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105 reviews)
"Middle of nowhere hotel was ok"
United States
David
The price is AU$100
includes taxes & fees
21 Jan - 22 Jan
Eagle Inn Charleston

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42 reviews)
"Very clean room, friendly staff! I would highly recommend this place! "
United States
Lydia
The price is AU$158
includes taxes & fees
1 Feb - 2 Feb
MainStay Suites Union City, TN
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

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Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters: This holiday home rental outside of East Prairie is located on a lake, and has a fireplace, a patio and a BBQ to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 32 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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