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Check prices for these dates

This weekend
5 June - 7 June
Next weekend
12 June - 14 June

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,006 reviews)
"Breakfast was good,pool hot tub excellent "
United States
Janica
The price is AU$179
includes taxes & fees
8 June - 9 June
Drury Inn & Suites Sikeston, MO
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (571 reviews)
"Ok place to say the night if you are looking for a place to sleep. "
United States
Paul
The price is AU$105
includes taxes & fees
6 June - 7 June
Country Hearth Inn & Suites Union City
Premier Room, 1 Bedroom, Non Smoking

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (767 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is AU$78
includes taxes & fees
7 June - 8 June
New Orleans Inn Portageville
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (518 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is AU$103
includes taxes & fees
30 June - 1 July
Quality Inn Union City US 51
Room, 1 Queen Bed, Non Smoking

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (64 reviews)
"Great hotel for the price!!! Remodel very nice and modern. "
United States
Amy
The price is AU$137
includes taxes & fees
7 June - 8 June
Super 8 By Wyndham Marston
Individually decorated, individually furnished, desk, blackout curtains

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (786 reviews)
"We were very satisfied with our stay. We will make this a regular stay when traveling to or from Iowa."
United States
Carolyn
The price is AU$92
includes taxes & fees
21 June - 22 June
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (413 reviews)
"All very just okay "
United States
Sherry
The price is AU$117
includes taxes & fees
6 June - 7 June
The Riverstone Hotel Charleston-Sikeston
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (84 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is AU$174
includes taxes & fees
21 June - 22 June
Fairfield Inn & Suites by Marriott Sikeston
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (637 reviews)
"Clean rooms,"
United States
Karl
The price is AU$93
includes taxes & fees
14 June - 15 June
Super 8 by Wyndham Charleston/Sikeston East MO
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (395 reviews)
"Great stay. "
United States
Paul
The price is AU$132
includes taxes & fees
30 June - 1 July
Sleep Inn at Discovery Park of America
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (573 reviews)
"Very clean hotel with comfortable bedding. Front desk staff was very nice and accommodating as we were traveling with a small dog."
United States
Connie
The price is AU$168
includes taxes & fees
21 June - 22 June
Hampton Inn Sikeston
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,004 reviews)
"Very convenient and staff was great."
United States
jeanne
The price is AU$146
includes taxes & fees
14 June - 15 June
Best Western Plus Sikeston I-55
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (286 reviews)
"the hotel needs updateing poor brekfesr"
United States
DANIEL
The price is AU$108
includes taxes & fees
13 June - 14 June
Quality Inn Cairo I-57
Iron/ironing board, free WiFi, bed sheets

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (139 reviews)
"Enjoyed our stay. All the appliances worked and our air conditioner kept us cool! Will definitely stay here again!"
United States
Sheryl
The price is AU$86
includes taxes & fees
6 June - 7 June
Country Yard Inn and Suite
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,002 reviews)
"When I stay at hotels I like to find hotels like this one for the $$$ value . This hotel was clean and the bed was very comfortable. Room 237 . I didn’t hear any interstate noise . I didn’t eat the breakfast but the coffee was very good . I would stay here again ."
United States
Kurt
The price is AU$114
includes taxes & fees
7 June - 8 June
Days Inn and Suites by Wyndham Sikeston
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (393 reviews)
"Yes"
United States
Lashae
The price is AU$95
includes taxes & fees
10 June - 11 June
Hospitality House Union City I 69 / US 51
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
"Room was very nice and in very clean condition and hotel staff was very helpful and polite. The breakfast was very delicious and coffee served all day. The hotel smelled very nice and had a very welcoming feeling. Will definitely book with them again"
United States
Joseph
The price is AU$202
includes taxes & fees
11 June - 12 June
TownePlace Suites by Marriott Sikeston
Standard Room, 2 Double Beds, Non Smoking

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (494 reviews)
"The lake view was beautiful and staff was amazing"
United States
Richard
The price is AU$105
includes taxes & fees
7 June - 8 June
Reelfoot Lake Inn
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (466 reviews)
"Only stayed one night, no complaints"
United States
Zachary
The price is AU$170
includes taxes & fees
21 June - 22 June
Holiday Inn Express & Suites Sikeston Southwest by IHG
Exterior

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (293 reviews)
"nice room, clean. breakfast was great and lady keeping it full, hot, and clean!"
United States
Fred
The price is AU$155
includes taxes & fees
28 June - 29 June
Comfort Inn & Suites Sikeston I-55
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

4.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean rooms and was ready when we arrived. We did not use the pool but other guests were enjoying it. Breakfast and Kick back were both great meals."
Emily 1-night trip
Posted 3 hours ago
Drury Inn & Suites Sikeston, MO

More cheap accommodation in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is AU$92 per night from 21 June to 22 June
AU$92
21 June - 22 June
includes taxes & fees
8.4/10 Very Good! (786 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
The Tackle Box at Reelfoot: This holiday home rental outside of East Prairie has air conditioning and WiFi to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop and a microwave. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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