East Prairie Hotel & Accommodation Deals 2026 from AU$92 - Compare prices by date

A tree-lined landscape with a river and fields.

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Go beyond your typical stay in East Prairie

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Our top choices for East Prairie hotels

A building with a fountain and flower beds in front.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

1. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

AU$107

includes taxes & fees

22 Oct - 23 Oct

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

2. Drury Inn & Suites Sikeston, MO

Sikeston

Tim

AU$155

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

3. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

AU$98

includes taxes & fees

22 Oct - 23 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

4. Best Western Plus Sikeston I-55

Sikeston

Shelley

AU$130

includes taxes & fees

8 Nov - 9 Nov

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

5. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Roslyn

AU$165

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A reception area with a counter, a flat-screen TV, and a window with blinds.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

6. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

AU$95

includes taxes & fees

21 Oct - 22 Oct

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

7. Hampton Inn Sikeston

Sikeston

Lori

AU$172

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A breakfast buffet counter with a bakery section and a display for breakfast items.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

8. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

AU$158

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

9. TownePlace Suites by Marriott Sikeston

Sikeston

Rubin

AU$178

includes taxes & fees

29 Oct - 30 Oct

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

10. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

AU$108

includes taxes & fees

1 Nov - 2 Nov

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A living room with two sofas, a coffee table, a TV, and a cabinet.

11. Comfort Inn & Suites Sikeston I-55

Sikeston

Fred

AU$129

includes taxes & fees

15 Nov - 16 Nov

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A bathroom with a bathtub, toilet, and shower curtain.

A reception area with a counter, a coffee machine, and seating.

12. Country Yard Inn and Suite

Sikeston

William

AU$93

includes taxes & fees

26 Oct - 27 Oct

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

13. Eagle Inn Charleston

Charleston

Jackson

AU$106

includes taxes & fees

21 Oct - 22 Oct

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

14. Super 8 By Wyndham Marston

Marston

Brenda

AU$92

includes taxes & fees

25 Oct - 26 Oct

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.

A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

A corridor with a vending machine displaying various beverages and a wall with hanging products.

15. Sleep Inn at Discovery Park of America

Union City

Ben

AU$124

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A motel with a covered entrance, multiple rooms, and a parking lot.

16. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Laura

AU$93

includes taxes & fees

27 Oct - 28 Oct

A hotel lobby with a reception desk, seating area, and a large window.

A hotel room with a desk, chair, television, and a lamp.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

17. Quality Inn Cairo I-57

Cairo

Santiago

AU$108

includes taxes & fees

13 Nov - 14 Nov

A hotel dining area with a long counter, multiple tables, and chairs. There are curtains on the windows, a lamp, and a view of the outdoors.

A gym with treadmills, elliptical machines, and stationary bikes.

A hotel room with a large bed, a desk, a chair, and a bedside table.

A reception area with a wooden counter, a television, and a sign for 'Quality Inn by Marriott'.

18. Quality Inn Union City US 51

Union City

Logan

AU$114

includes taxes & fees

10 Nov - 11 Nov

A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

A modern meeting room with red and grey chairs, a large flat-screen TV, and a wooden cabinet with decorative items.

A hotel room with two beds, a desk, and a large window offering a view.

A modern office space with a long desk, two chairs, and a computer. There are multiple tables and chairs in the background, and a colorful striped artwork on the wall.

19. Holiday Inn Express & Suites Union City by IHG

Union City

Kevin

AU$201

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with a fire pit, cushioned chairs, and a metal fence.

A hotel lobby with a long counter, multiple seating areas, and a modern chandelier.

An indoor swimming pool with a no diving sign, lounge chairs, and a no diving sign at the bottom.

A modern hotel lobby with multiple seating areas, a kitchen in the background, and large windows with curtains.

20. Hampton Inn Union City

Union City

Melody

AU$174

includes taxes & fees

1 Nov - 2 Nov

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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Super 8 By Wyndham Marston

8/10 Good

"Got there late and staff was very helpful. Room was clean and comfortable"

Hampton Inn Sikeston

10/10 Excellent

"Every part of this stay was excellent, from check in to check out. Helpful and friendly staff, wonderful, clean and well furnished room, delicious breakfast. Highly recommend."

Hampton Inn Union City

10/10 Excellent

"Very clean Comfy beds Good variety of breakfast items"

Quality Inn Union City US 51

10/10 Excellent

"Awesome"

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"good, clean, affordable :)"

Sleep Inn at Discovery Park of America

8/10 Good

"Everything was nice. Bed very comfortable."

Reelfoot Lake Inn

8/10 Good

"Dated but descent."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean, comfortable room. Nice staff and good breakfast choices."

More cheap accommodation in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

AU$93

27 Oct - 28 Oct

includes taxes & fees

7/10 Good! (688 reviews)

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

AU$95

21 Oct - 22 Oct

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

AU$108

1 Nov - 2 Nov

includes taxes & fees

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

AU$124

15 Nov - 16 Nov

includes taxes & fees

9.2/10 Wonderful! (438 reviews)

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

AU$130

8 Nov - 9 Nov

includes taxes & fees

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

AU$172

1 Nov - 2 Nov

includes taxes & fees

9/10 Wonderful! (646 reviews)

Frequently asked questions

What is the best area to stay in East Prairie?

The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.For travellers looking for a straightforward and practical base, staying near Main Street is ideal.

When is the best time to go to East Prairie?

The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.

How can I save on a hotel booking in East Prairie with Expedia?

One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on East Prairie hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

How much is the nightly rate for a hotel in East Prairie?

Prices for hotels in East Prairie often vary, but you can find a great deal from AU$92 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Search East Prairie hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in East Prairie

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for East Prairie hotels

1. The Riverstone Hotel Charleston-Sikeston

2. Drury Inn & Suites Sikeston, MO

3. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

4. Best Western Plus Sikeston I-55

5. Fairfield Inn & Suites by Marriott Sikeston

6. Super 8 by Wyndham Charleston/Sikeston East MO

7. Hampton Inn Sikeston

8. Holiday Inn Express & Suites Sikeston Southwest by IHG

9. TownePlace Suites by Marriott Sikeston

10. Days Inn and Suites by Wyndham Sikeston

11. Comfort Inn & Suites Sikeston I-55

12. Country Yard Inn and Suite

13. Eagle Inn Charleston

14. Super 8 By Wyndham Marston

15. Sleep Inn at Discovery Park of America

16. Super 8 by Wyndham Sikeston/Miner Area

17. Quality Inn Cairo I-57

18. Quality Inn Union City US 51

19. Holiday Inn Express & Suites Union City by IHG

20. Hampton Inn Union City

Stay near popular East Prairie attractions

Big Oak Tree State Park

Learn more about East Prairie

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Super 8 By Wyndham Marston

Hampton Inn Sikeston

Hampton Inn Union City

Quality Inn Union City US 51

Super 8 by Wyndham Sikeston/Miner Area

Sleep Inn at Discovery Park of America

Reelfoot Lake Inn

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Holiday Inn Express & Suites Sikeston Southwest by IHG

More cheap accommodation in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Charleston/Sikeston East MO

Days Inn and Suites by Wyndham Sikeston

Sleep Inn at Discovery Park of America

Best Western Plus Sikeston I-55

Hampton Inn Sikeston

Frequently asked questions

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