Book St. Charles County Hotels

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Top Cities in St. Charles County

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for St. Charles County hotels

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very good, (1005)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is AU$293
includes taxes & fees
21 Dec - 22 Dec
Ameristar Casino Resort and Spa

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1010)
"Great staff, clean room. "
United States
Amanda
The price is AU$155
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn St. Charles St. Peters

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
St. Charles
8.6 out of 10, Excellent, (1008)
"I Loved it I would definitely stay there again"
United States
Roberta
The price is AU$212
includes taxes & fees
28 Dec - 29 Dec
Embassy Suites by Hilton St. Louis St. Charles

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1000)
"The staff were awesome "
United States
Corey
The price is AU$193
includes taxes & fees
28 Dec - 29 Dec
Country Inn & Suites by Radisson, St. Charles Historic District

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1004)
"Staff and hotel were amazing"
United States
Allison
The price is AU$201
includes taxes & fees
28 Dec - 29 Dec
Drury Plaza Hotel St. Louis St. Charles

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1006)
"Nice staff at reception. "
United States
Denise
The price is AU$133
includes taxes & fees
28 Dec - 29 Dec
Comfort Suites St Charles - St Louis

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
St. Charles
8.0 out of 10, Very good, (1009)
"The room is decent for a night. The price is great and hotel staff is friendly. "
United States
Jordan
The price is AU$152
includes taxes & fees
18 Dec - 19 Dec
Best Western Plus The Charles Hotel

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.6 out of 10, (1001)
"Great place to stay "
United States
Askar
The price is AU$105
includes taxes & fees
31 Dec - 1 Jan 2026
Relax Inn Saint Charles

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (834)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is AU$148
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
St. Charles
5.8 out of 10, (1005)
"Nice staff, respectful."
United States
LaurenRenee
The price is AU$104
includes taxes & fees
21 Dec - 22 Dec
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO
2.5 star property
St. Charles
8.6 out of 10, Excellent, (768)
"Great staff and room was so nice and comfortable "
United States
ED
The price is AU$156
includes taxes & fees
28 Dec - 29 Dec
Tru by Hilton St. Charles St. Louis, MO

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.2 out of 10, Wonderful, (632)
"Clean room, great staff, liked the gym"
United States
Emily
The price is AU$178
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites St. Charles Old Town Area

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1000)
"The front desk agent was super nice and the rooms are always clean. They have the best beds in a hotel!"
United States
Jessica
The price is AU$146
includes taxes & fees
21 Dec - 22 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very good, (1000)
"I'd stay at this place again. "
United States
Suzanne
The price is AU$131
includes taxes & fees
25 Dec - 26 Dec
Super 8 by Wyndham St Charles

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1005)
"Great hotel! Clean, friendly staff, wonderful amenities!"
United States
Susan
The price is AU$191
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites St. Louis St. Peters

Candlewood Suites St Louis St Charles by IHG

Candlewood Suites St Louis St Charles by IHG
2.5 star property
St. Charles
7.6 out of 10, Good, (754)
"Great place to stop to! "
United States
Neil
The price is AU$132
includes taxes & fees
21 Dec - 22 Dec
Candlewood Suites St Louis St Charles by IHG

Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.2 out of 10, Very good, (1003)
"This was an amazing stay"
United States
Madison
The price is AU$156
includes taxes & fees
21 Dec - 22 Dec
Country Inn & Suites by Radisson, St. Peters, MO

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.8 out of 10, Exceptional, (18)
"The room was super clean and tidy. The staff was very friendly and overall a great experience. "
United States
Fred
The price is AU$128
includes taxes & fees
18 Dec - 19 Dec
WoodSpring Suites St Peters-OFallon

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1002)
"Great front desk experience, no issues booking same day!"
United States
Tracy
The price is AU$139
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn & Suites St. Louis - O'Fallon

Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (718)
"Clean room, quiet"
United States
Laura
The price is AU$151
includes taxes & fees
28 Dec - 29 Dec
Hilton Garden Inn St. Louis/O'Fallon MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in St. Charles County, MO

Showing deals for:26 Dec - 28 Dec
Save an average of 15% on thousands of hotels when you're signed in

Top St. Charles County Hotel Reviews

Explore a world of travel with Expedia