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Top Cities in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.
HotelsHotels

Charleston

Charleston
A tree-lined landscape with a river and fields.
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East Prairie

East Prairie

Check prices for these dates

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

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Our top choices for Mississippi County hotels

A building with a fountain and flower beds in front.

1. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is AU$106
includes taxes & fees
2 Nov - 3 Nov
The Riverstone Hotel Charleston-Sikeston
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (680 reviews)
"Breakfast was light but good"
United States
zandra
The price is AU$95
includes taxes & fees
1 Nov - 2 Nov
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is AU$105
includes taxes & fees
28 Oct - 29 Oct
Eagle Inn Charleston
A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (296 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is AU$109
includes taxes & fees
15 Nov - 16 Nov
Quality Inn Cairo I-57
A hot tub with a wooden deck and outdoor seating area.

5. The Roost | Hot Tub, Ponds & Farm Views

The Roost | Hot Tub, Ponds & Farm Views
Carlisle County
The price is AU$298
includes taxes & fees
28 Oct - 29 Oct
The Roost | Hot Tub, Ponds & Farm Views
A hot tub in an outdoor setting with a wooden deck and lounge chairs.

6. Perfect Couples Retreat - firepit

Perfect Couples Retreat - firepit
Carlisle County
The price is AU$268
includes taxes & fees
28 Oct - 29 Oct
Perfect Couples Retreat - firepit
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

8/10 Good
"We had a two-room room king suite. The only complaint I had was that it took 5-10 minutes for the hot water to get hot. They did offer to give me points for a free stay if I wanted to sign-up for their rewards program. We will there next year when we go through Sikeston MO."
Byron E. Shryock 1-night trip
Posted 13 hours ago
Drury Inn & Suites Sikeston, MO