Book Mississippi County Hotels

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
1 Oct - 2 Oct
Tomorrow
2 Oct - 3 Oct
This weekend
3 Oct - 5 Oct
Next weekend
10 Oct - 12 Oct

Filter by

Guest rating
Guest rating
Star rating

Top Hotels in Mississippi County

Super 8 by Wyndham Charleston/Sikeston East MO
Front of property – evening/night

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (593)
"Thank you!!!"
The price is AU$96
includes taxes & fees
5 Oct - 6 Oct
Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Charleston - Sikeston
Desk, laptop workspace, blackout curtains, iron/ironing board

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (403)
"I consistently choose to stay there due to positive past encounters."
The price is AU$110
includes taxes & fees
26 Oct - 27 Oct
Quality Inn Charleston - Sikeston
Eagle Inn Charleston
Desk, iron/ironing board, free WiFi, alarm clocks

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (101)
"Comfortable bed, easy access to room"
The price is AU$107
includes taxes & fees
7 Oct - 8 Oct
Eagle Inn Charleston
Quality Inn Cairo I-57
Lobby

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (270)
"Break fast was excellent "
The price is AU$114
includes taxes & fees
27 Oct - 28 Oct
Quality Inn Cairo I-57
Charming 3-bedroom house near ball park in quiet neighborhood
Fridge, microwave, oven, stovetop

Charming 3-bedroom house near ball park in quiet neighborhood

10.0 out of 10, Exceptional, (10)
"Quaint stay to see Grand and kids. "
The price is AU$246
includes taxes & fees
2 Oct - 3 Oct
Charming 3-bedroom house near ball park in quiet neighborhood
The Hickory Chicken "Hard to find, worth the search"
Terrace/patio

The Hickory Chicken "Hard to find, worth the search"

The price is AU$270
includes taxes & fees
28 Oct - 29 Oct
The Hickory Chicken "Hard to find, worth the search"
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mississippi County Hotel Reviews

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

10/10 Excellent
"So far other than not being able to order an uber in this area... the hotel stat is pleasent.... its very clean, ive seen no bugs in my room yet... and the staff is just very warming and polite from the start"
Gerald 1-night trip
Posted 22 hours ago
Hospitality House Union City I 69 / US 51

Explore a world of travel with Expedia

Explore a world of travel with Expedia