A bridge over a muddy river with green trees and hills in the background.

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Top Cities in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.
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Charleston

Charleston
A tree-lined landscape with a river and fields.
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East Prairie

East Prairie

Check prices for these dates

Next weekend
18 Sept - 20 Sept
In two weeks
25 Sept - 27 Sept

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Our top choices for Mississippi County hotels

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

1. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (666 reviews)
"Canceled"
United States
Crystal
The price is AU$92
includes taxes & fees
17 Sept - 18 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
A building with a fountain and flower beds in front.

2. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (432 reviews)
"Everything was fine for a one night stay."
United States
Jay
The price is AU$103
includes taxes & fees
14 Sept - 15 Sept
The Riverstone Hotel Charleston-Sikeston
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is AU$119
includes taxes & fees
14 Sept - 15 Sept
Eagle Inn Charleston
A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (295 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is AU$108
includes taxes & fees
9 Oct - 10 Oct
Quality Inn Cairo I-57
A bedroom with a bed, a nightstand, a wall-mounted TV, and a door.

5. The Roost | Hot Tub, Ponds & Farm Views

The Roost | Hot Tub, Ponds & Farm Views
Carlisle County
The price is AU$293
includes taxes & fees
14 Sept - 15 Sept
The Roost | Hot Tub, Ponds & Farm Views
A wooden deck with a colorful rug featuring a tiger design, a white metal chair, and a door.

6. Perfect Couples Retreat - firepit

Perfect Couples Retreat - firepit
Carlisle County
The price is AU$263
includes taxes & fees
13 Sept - 14 Sept
Perfect Couples Retreat - firepit
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent
"Canceled"
Crystal 4-night trip
Posted 23 hours ago
Super 8 by Wyndham Charleston/Sikeston East MO