Luxury Hotels & Resorts in Charleston

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Best Charleston Luxury Hotels

Top Charleston Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Enjoyed everything "
Marvin 1-night trip
Posted 10 days ago
Drury Inn & Suites Sikeston, MO
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

10/10 Excellent
"Great staff and breakfast. There was a 50$ deposit in case anything got broke we had to pay at check in that we didn't know about. So that needs to be clearer on the website, but otherwise it was affordable, clean, and multiple restaurants in walking distance. Even a Starbucks nextdoor"
Kendall 1-night trip
Posted 3 weeks ago
Pear Tree Inn Cape Girardeau Near the Medical Center

Frequently asked questions

Are you searching for the perfect hotel for your luxury holiday in Charleston?
Expedia can help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then you can select from various places to stay that will deliver the luxury you'd like to find. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Charleston offers. During your visit, you might want to enjoy the restaurants which Charleston is known for.
When can I expect good weather in Charleston?
Planning for the weather is an important factor for making your trip to Charleston a success, especially when you're splurging. The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Charleston is 1509 mm.
What's there to see and do in Charleston?
Enjoy Charleston with a stop at Mississippi River, Ohio River and Sikeston Depot Museum. If you have spare time during your trip, you might want to make a stop at Columbus-Belmont State Park and Big Oak Tree State Park.