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The best area to stay in Buffalo, South Carolina, is near the intersection of Main Street and South Carolina Highway 215, as this is the most developed part of the town.


This central area offers the most convenience for visitors. You'll find the Buffalo Post Office and a few local shops and eateries clustered around this junction. It's a small, rural community, and this intersection serves as its commercial heart.


For solo travellers or couples looking for a quiet retreat, staying in this area provides easy access to the local amenities and a sense of the community.

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Buffalo.

One Key™—Expedia’s free travel rewards program—gives you instant access to discounts with Member Prices on Buffalo hotels. Plus, you’ll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

Prices for hotels in Buffalo often vary, but you can find a great deal from AU$76 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.