Near the village of Gorno Nerezi and only 20 min drive from Skopje city centre, high on the forested slopes of Vodno mountain, the 12th century church of St. Panteleimon is founded. It is one of the oldest and most important churches in Macedonia, built and painted in 1164 under the patronage of Byzantine Prince Alexios Komnenos whose name is made immortal by being carved in marble, right above the entrance in the church. It was dedicated to St. Panteleimon, the protector of health.

The biggest Roman site in Macedonia dates from 1st century AD. Well preserved Roman amphitheatre, unique mosaics, the Baptistery and many more makes this site most see.

The small Wine museum of Tikvesh region is founded in the city of Kavadarci, the centre of Tikvesh wine region. An interesting exhibition of local heritage connected with wine making and production.

Afternoon arrival to the biggest wine region in Macedonia - Tikvesh, located in the very heart of the country and stretches along similar latitudes as the Bordeaux region in France, Tuscany region in Italy and the Napa Valley region in California. The wine district is situated on around 2,000 sqm of fertile land, surrounded by mountains on three sides. With nearly 13,000 hectares of vines, the Tikves wine region represents around one third of the all grapes grown in Macedonia, a place where the southern Mediterranean climate, full of long and warm summers and the northern continental climate, with mild and rainy winters, combine. Because of smooth climate and plenty of sunny days, grapes and wine producing is traditional occupation for the locals ever since ancient times. High quality grape types such as Sauvignon, Vranec, and Merlot are just a part of the unique taste of Macedonian wines. Another famous Macedonian brand named “Rakija” (a fiery brandy) is produced in this region.