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Top Fishing Eastern South Dakota Hotels

Lewis and Clark Resort

43496 Shore Drive Yankton SD

2 hours drive from Denny Sanford Premier Center

Stay at this beach hotel in Yankton. Enjoy free Wi-Fi, free parking and an outdoor pool. Popular attractions Lewis and Clark Recreation Area and Midway Recreation ...

8.8/10 Excellent! (284 reviews)

Rooms are clean, no frills, place is quiet. Nicely priced. Way better than a hotel.

Reviewed on 9 Dec 2025

Cabin on bluff of Big Sioux River with rushing waters of the Klondike Dam below.

Larchwood IA

44 min drive from Denny Sanford Premier Center

Stay at this holiday home in Larchwood. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Lake Alvin Recreation Area and Lake Alvin Beach ...

9.8/10 Exceptional! (184 reviews)

Host was very prompt with replies to questions. Great location! Loved the view of the river from the hot tub. Nice short walk to the river bridge, beautiful.House had everything we needed, loved the large dining table. Worked perfect for out group of 7 women.Would love to stay here again!

Reviewed on 26 Nov 2025

Comfort Inn Yankton SD

611 W 23rd Street Yankton SD

2 hours drive from Denny Sanford Premier Center

Stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...

8.8/10 Excellent! (666 reviews)

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Reviewed on 11 Dec 2025

See all 901 properties in Eastern South Dakota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.