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Top Adventure Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8.2/10 Very Good! (1,875 reviews)

Clean and quiet

Reviewed on 4 Feb 2026

Country Inn & Suites by Radisson, Rochester, MN

4323 Highway 52 North, West Frontage Rd Rochester MN

10 min drive from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...

7.4/10 Good! (1,001 reviews)

Room is clean. Staff was courteous.

Reviewed on 23 Jan 2026

AmericInn by Wyndham Mankato Event Center

240 Stadium Road Mankato MN

4 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Mankato. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

9/10 Wonderful! (1,002 reviews)

Staff was very nice and polite Rooms are spacious and clean

Reviewed on 28 Jan 2026

See all 1,199 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.