Photo by Southernmost Illinois Tourism Bureau

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Top Adventure Southwest Illinois Hotels

SureStay Hotel by Best Western Whittington Rend Lake

13277 Freeway Lane Whittington IL

1 hour drive from Southern Illinois University

Stay at this business-friendly hotel in Whittington. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.8/10 Excellent! (983 reviews)

"It was good minus in our room the bathroom door sticks really bad and got stuck"

Reviewed on 22 June 2026

Hampton Inn Carbondale

2175 Reed Station Pkwy Carbondale IL

10 min drive from Southern Illinois University

Stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.4/10 Very Good! (650 reviews)

"Everything was almost perfect! Big disappointment to be told at check-in that pool would be down my whole stay!"

Reviewed on 20 June 2026

Days Inn & Suites by Wyndham Caseyville

2423 Old Country Inn Drive Caseyville IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Caseyville. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Popular attractions Pleasant Ridge Park and Cahokia ...

4/10 (351 reviews)

"1st room had no microwave, no fridge, no AC. 2nd room had no ac, shower was full of hair, missing outlets. Beds were soft, desk lady found us a fan, and it was quiet. Property amenities were missing. No pool, no game room, no breakfast, crime scene tape over one door. Windows opened but didn't have ..."

Reviewed on 10 June 2026

See all 758 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.