Top Adventure Southeast Missouri Hotels

Hampton Inn Farmington

850 Valley Creek Dr, Farmington, MO

2 hours drive from Mark Twain National Forest

Stay at this hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.8/10 Excellent! (508 reviews)

Amazing hotel! Our room, the lobby, and breakfast area were so clean. Staff were very welcoming and helpful. Our beds were so comfortable. The hotel lobby was beautifully decorated for Halloween. The breakfast options were delicious.

Reviewed on 13 Oct 2025

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd, Farmington, MO

2 hours drive from Mark Twain National Forest

Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (557 reviews)

We enjoyed that is was very quiet. And the room was very big. Slept very comfortable.

Reviewed on 22 Oct 2025

Echo Bluff State Park

34489 Echo Bluff Dr, Eminence, MO

43 min drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Eminence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Echo Bluff State Park and ...

9.4/10 Exceptional! (211 reviews)

Great staff!!

Wonderful, beautiful place but the lodge does not accomodate pets. Staff was gracious and made arrangements for us. Staff was extraordinary and dining experience was slow but great food.

Reviewed on 25 Oct 2025

See all 597 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.