Southeastern Indiana Holidays

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Your Southeastern Indiana Holiday

Leave the travel planning up to us with a Southeastern Indiana holiday package. With everything organised before you jet off, the only thing left for you to do is sit back, relax and experience this destination's many wonders. Louisville, Clarksville and Jeffersonville are a few of the most popular cities here. Make sure your trip to Southeastern Indiana includes a visit to at least one of them! From the instant you book your Southeastern Indiana holiday to the second you come back home, Expedia has your back every step of the way.

Our guide on where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana
West Main Historic District

West Main Historic District

A noteworthy feature of West Main Historic District is its fantastic nightlife. While you're in town, be sure to stop and check out Frazier International History Museum and Louisville Slugger Museum.

Find hotels in West Main Historic District

Southeastern Indiana Holiday

Southeastern Indiana Essential Information

Language
English
Currency
U.S dollars
Closest Airport
O'Hare Intl. Airport (ORD)
Top Sights
Louisville Mega Cavern, Louisville Zoo and Clifty Falls State Park

Our pick of the best Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Fully refundableReserve now, pay when you stay
The price is AU$102 per night from 13 Apr to 14 Apr
AU$102
13 Apr - 14 Apr
includes taxes & fees
7/10 Good! (2,925 reviews)
The television never worked right on my two day stay. It was always searching for a signal. Very frustrating

Reviewed on 6 Apr 2026

Radisson Hotel Louisville North
Derby Hotel & Suites

Derby Hotel & Suites

2 out of 5
505 K Marriot Dr Clarksville IN
Fully refundable
The price is AU$88 per night from 14 Apr to 15 Apr
AU$88
14 Apr - 15 Apr
includes taxes & fees
5.6/10 (14 reviews)
Yes us and the kids loved the pool area and had a blast on our trip.

Reviewed on 31 Mar 2026

Derby Hotel & Suites
Motel 6 Jeffersonville, In - Louisville

Motel 6 Jeffersonville, In - Louisville

2 out of 5
2012 Hospitality Way Clarksville IN
Fully refundableReserve now, pay when you stay
The price is AU$92 per night from 19 Apr to 20 Apr
AU$92
19 Apr - 20 Apr
includes taxes & fees
6.2/10 (420 reviews)
The room I was assigned had been renovated so it was comfortable, floors had not been properly cleaned, some water was spilled and when i wiped it up the white paper towel turned a light brown. The hallways were old, dated and poorly kept, litter was laying in various spots. No breakfast area, nearest ...

Reviewed on 5 Apr 2026

Motel 6 Jeffersonville, In - Louisville
See all 1,157 properties in Southeastern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
All Inclusive Holidays
Cheap Holidays
Cheap Holidays
Cheap Holidays
beach holidays
Beach Holidays
Beach Holidays

Discover the most popular places to visit in Southeastern Indiana

Panorama Ohio River waterway riverboats and bridges leading to heart of downtown Louisville KY

KFC Yum Center

Catch an event at KFC Yum Center during your trip to Louisville. Stroll along the riverfront or attend a sporting event in the area.

KFC Yum Center
Big Clifty Falls, a beautiful waterfall in Clifty Falls State Park by Madison, Indiana, plunges over a cliff at the head of a rugged rocky canyon as the creek flows down to the nearby Ohio River.

Clifty Falls State Park

You can take time to visit Clifty Falls State Park during your travels to Madison. Stroll along the riverfront or discover the area's waterfalls.

Clifty Falls State Park
Muhammad Ali Center

Muhammad Ali Center

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

Muhammad Ali Center

Frequently asked questions

Can I cancel my flight booking to Southeastern Indiana due to COVID-19?
If you haven't booked yet, check the terms and conditions of the airline you're considering. If you've already reserved your flight to Southeastern Indiana, head to our Customer Service Portal. The information here will help determine which COVID-19 policies apply to your booking and provide advice on the next steps.
What's the best way to find cheap flights to Southeastern Indiana that have flexible change policies?
It's as easy as 1-2-3 with Expedia. Firstly, type in your preferred dates and destination and press "Search." Next, check the "No change fee" box directly below the "Flexible change policies" subheading to the left of the screen. Step 3. Reserve a cheap and flexible airfare to Southeastern Indiana.
What are some of the general tips for travellers to Southeastern Indiana during the COVID-19 outbreak?
With strict COVID-19 precautions to adhere to, travel looks a bit different these days. Here's what you should know before you jet off to Southeastern Indiana:
  • Research if any travel restrictions apply to your origin and destination before locking in a flight. Also check if there are any conditions you'll have to follow on arrival, such as proof of a negative COVID-19 test.
  • You must wear a face mask at the airport, including at security checkpoints. You should be prepared to lower your mask for identification purposes when asked by a TSA employee.
  • To minimize the risk of cross-contamination, place your boarding pass on the reader yourself and then hold it up for inspection. Do not hand your pass directly to a TSA officer.
  • TSA now allows passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on bags. This will need to be removed from your bag at the X-ray machine for screening.
  • Place any personal items (e.g, keys, phone and wallet) in your carry-on instead of a bin to minimize handling during screening.
  • Transport all food items in a clear plastic bag and also place them in a screening bin. Keeping food separate from your carry-on makes it less likely that a TSA officer will need to touch and open your bag for inspection.

Which airlines fly to Southeastern Indiana?
Let American Airlines fly you there. This renowned carrier operates 13307 services per month to O'Hare Intl. Airport (ORD), a Southeastern Indiana gateway.
How can I find cheap tickets to Southeastern Indiana?
An effective strategy for picking up cheap fares is to be flexible with your travel dates. Start by searching for your flight to Southeastern Indiana, then click on the "flexible dates" link to see prices for nearby days. Another handy tip? Book well ahead. For an idea of costs, was the best price for a flight to Southeastern Indiana in the last seven days.
How much is a flight to Southeastern Indiana?
In the last seven days, round-trip airfares to Southeastern Indiana sold for as low as and reached a maximum price of . For one-way journeys departing from (), the lowest price during this time was only .
What are the most popular airports to fly into in Southeastern Indiana?
Fly into O'Hare Intl. Airport (ORD) and sample the best that Southeastern Indiana has to offer. As the region's main point of entry, roughly 33491 flights land here every month.
When is the cheapest time to fly to Southeastern Indiana?
Leave for Southeastern Indiana earlier in the week and you'll usually be rewarded with more affordable fares. Tuesday is generally the cheapest day to jump on a plane, followed closely by Monday. If you'd like to avoid the priciest flights, steer clear of Saturdays.
How much is a plane ticket to Southeastern Indiana?
In the last seven days, airfares ranged between and . Scroll through our sensational deals to Southeastern Indiana, pick your favourite and then get ready for your getaway!
Which airlines with flights to Southeastern Indiana employ COVID-19 cleanliness policies?
While flying in the middle of a pandemic can be nerve-wracking, airlines have been working hard to ensure the well-being of all on board. Here are a few carriers that have implemented changes:
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.