Santo Antonio Holidays

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Your Santo Antonio Holiday

From its shopping to its cafes and culture, there are tons of good reasons to book a holiday package to Santo Antonio. When you need to get away from it all, this commercial neighbourhood has a spot just for you. When it's time to sightsee, you'll find plenty of big-name attractions nearby including Castle of São Jorge, Rossio Square and Lisbon Cathedral. Tick off one or all during your trip to Santo Antonio. Expedia is here to put your travel plans into action. Book your ultimate Santo Antonio holiday today.

Santo Antonio Holiday

Our pick of the best Santo Antonio Hotel Deals

Locke de Santa Joana

Locke de Santa Joana

18 Rua Camilo Castelo Branco Lisbon
Fully refundableReserve now, pay when you stay
AU$160
1 Nov - 2 Nov
includes taxes & fees
Locke de Santa Joana
easyHotel Lisbon

easyHotel Lisbon

R. de Santa Marta 60 Lisbon
Fully refundableReserve now, pay when you stay
AU$117
2 Nov - 3 Nov
includes taxes & fees
8.8/10 Excellent! (1,747 reviews)
"Location . Shops & restaurant are nearby"

Reviewed on 5 Oct 2026

easyHotel Lisbon
Pestana Lisboa Vintage City Center Suites

Pestana Lisboa Vintage City Center Suites

Rua Braamcamp, 7 Lisbon
Fully refundableReserve now, pay when you stay
AU$203
1 Nov - 2 Nov
includes taxes & fees
8.8/10 Excellent! (747 reviews)
"I stayed with Pestana for 6 nights with my parents. Apartment was spacious and so so comfortable and cozy. Staff are very accommodating and helpful. Location is perfect . The on site restaurant food was very delicious. I loved the breakfast options . Loads of restaurants nearby . I wil definitely ..."

Reviewed on 6 Oct 2026

Pestana Lisboa Vintage City Center Suites
See all 703 properties in Santo Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santo Antonio attractions

A city square with a fountain, trees, and a building with 'SAO JOSE' signage.

Avenida da Liberdade

9.4/10 (3,467 reviews)
You can find the perfect gifts to bring home when you visit Avenida da Liberdade, a popular shopping spot in Santo Antonio. Discover the top-notch restaurants in this romantic area or seek out the local tours.
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A modern building with a large glass facade, a blue awning, and a sign for 'Caixa Geral de Deposicao'.

Amoreiras Shopping Center

8.0/10 (225 reviews)
You can find the perfect gifts to bring home at Amoreiras Shopping Center during your trip to Campo de Ourique. Amble around this vibrant area's riverfront or experience its fascinating museums.
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A bamboo archway pathway with a bench.

Botanical Garden

8.4/10 (800 reviews)
Portugal’s oldest botanical garden is a relaxing getaway from the bustling Lisbon streets and a great vantage point to admire the striking Tower of Belem.
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A fountain surrounded by trees, with a cityscape in the background.

Miradouro de São Pedro de Alcântara

8.8/10 (13 reviews)
You can learn about the history of Misericórdia with a trip to Miradouro de São Pedro de Alcântara. Amble around this vibrant area's riverfront or experience its fascinating museums.
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A grand hall with high ceilings, large columns, and banners hanging from the ceiling.

National Museum of Natural History

8.6/10 (17 reviews)
Learn about the geological makeup of Portugal and see models of the creatures that once roamed the earth at this interactive museum.
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A street with a Michael Kors store and a Maria João Batista building.

Coracao de Jesus

9.4/10 (3 reviews)
You can find out about the history of Santo Antonio with a stop at Coracao de Jesus. Make time for the shops and local tours in this romantic area.
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Cinemateca Portuguesa Museum

8.0/10 (3 reviews)
You can spend an afternoon exploring the galleries in Cinemateca Portuguesa Museum in Santo Antonio. Experience the acclaimed art galleries and fascinating museums in this family-friendly area.
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Medeiros e Almeida Museum

8.8/10 (6 reviews)
You can spend an afternoon browsing the exhibits at Medeiros e Almeida Museum in Santo Antonio. Discover the top-notch restaurants and acclaimed art galleries in this romantic area.
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What to do in Santo Antonio

Picture 3 for Activity Lisbon: Guided Day Tour of Sintra, Pena, Regaleira & Cascais

Lisbon: Sintra, Pena, Regaleira & Cabo Roca & Cascais Coast

AU$39
per adult
92% of travellers recommend
Lisbon: Sintra, Pena, Regaleira & Cabo Roca & Cascais Coast
Belem Tower

Tour Lisbon: Belém Tower, the Cathedral & Parque das Nações

AU$124
per adult
96% of travellers recommend
Tour Lisbon: Belém Tower, the Cathedral & Parque das Nações
Lisbon: Sintra, Pena, Regaleira, Cabo da Roca, and Cascais

Lisbon: Sintra, Pena, Regaleira, Cabo da Roca, and Cascais

AU$57
per adult
92% of travellers recommend
Lisbon: Sintra, Pena, Regaleira, Cabo da Roca, and Cascais
See all activities in Santo Antonio

Frequently asked questions

What are the cheapest months to go to Santo Antonio?
December, January and February are the best times to look for cheap Santo Antonio holiday packages. Opting to travel in less busy months means you can usually find lower prices on flights and hotels.
How many days is enough for Santo Antonio?
Generally, a handful of days is enough to visit the major sights during your Santo Antonio holiday. But if you want to have some time to rest or go on day trips, consider extending your itinerary.
Is it worth booking a holiday package to Santo Antonio?
Well known for its shopping, cafes and culture, a Santo Antonio holiday is a hit with all kinds of visitors. Be sure to visit main sights like Medeiros e Almeida Museum and Cinemateca Portuguesa Museum, and consider renting a set of wheels for day trips to discover even more.
How to find the best Santo Antonio package deals?
Bagging a cheap Santo Antonio package deal is a cinch with Expedia. Once you've entered your destination and preferred dates under our "Packages" tab, set your budget range, add some filters and browse what's available. You can tailor your search by "Amenities," "Property type," "Traveller experience" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Santo Antonio package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
When to book a holiday package to Santo Antonio?
If you're considering a spontaneous Santo Antonio adventure, browse our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can land incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santo Antonio?
  1. Choose your travel dates: What you'd like to do in Santo Antonio and your favourite season will help you decide when to get away.
  2. Set your budget: Factor in expenses like food, flights and transportation when working out how much to put aside for your trip to Santo Antonio. Then, select a hotel that suits your budget, whether that's a low-cost option or a swankier retreat.
  3. Decide how many days away: Start by compiling a list of the activities and attractions you want to get to in Santo Antonio. Then, estimate how long you'll need for each, including any travel time.
  4. Bundle your bookings: With your travel dates in place, you can combine your hotels, flights, car rental and more into a customised Santo Antonio holiday package.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.