Default HTG hotel image

Santa Maria Hotels, Guayaquil

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
31 July - 2 Aug
In two weeks
7 Aug - 9 Aug

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Maria hotels

Lobby

1. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 4.2 km from Santa Maria
8.8 out of 10, Excellent, (951 reviews)
"An excellent stay, good staff, clean room, and delicious food. I would stay there again without a doubt."
United States
MARTHA
The price is AU$170
23 Aug - 24 Aug
Hilton Colon Guayaquil
Café

2. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
5.5 km from Santa Maria
9.4 out of 10, Exceptional, (1,008 reviews)
"Great overnight stay. Lovely staff, excellent room and amenities and a great breakfast!"
Australia
Peter
The price is AU$145
9 Aug - 10 Aug
Holiday Inn Guayaquil Airport by IHG
Lobby

3. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1,001 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is AU$128
1 Aug - 2 Aug
Courtyard by Marriott Guayaquil
Rooftop bar, al fresco dining, open daily

4. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 4.8 km from Santa Maria
9.2 out of 10, Wonderful, (1,001 reviews)
"The room was really clean and the staff in the lobby were really helpful. Breakfast was good"
United States
Rosa
The price is AU$120
9 Aug - 10 Aug
Wyndham Garden Guayaquil
Terrace/patio

5. Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport
4.0 star property
Garzota, 4.9 km from Santa Maria
8.6 out of 10, Excellent, (275 reviews)
"Very clean and comfortable rooms. The staff was very friendly and they're all fluent in English and Spanish. Breakfast in the restaurant was also delicious."
United States
Myna-Maria
The price is AU$96
7 Aug - 8 Aug
Hotel Puerto Pacifico Guayaquil Airport
Outdoor pool, pool loungers

6. Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast
3.5 star property
3 km from Santa Maria
9.2 out of 10, Wonderful, (48 reviews)
"Breakfasts were excellent. Staff went out of their way to accommodate late arrival. "
Canada
Kimberly
The price is AU$161
26 July - 27 July
Iguanazu Bed & Breakfast
Reception

7. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1,004 reviews)
"Best place to stay, delicious food and the bed was a dream"
United States
Renata
The price is AU$137
23 Aug - 24 Aug
TRYP by Wyndham Guayaquil Airport
Property entrance

8. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 4.9 km from Santa Maria
9.2 out of 10, Wonderful, (709 reviews)
"Good hotel"
United States
juan pablo
The price is AU$145
26 July - 27 July
Radisson Hotel Guayaquil
Daily buffet breakfast for a fee

9. Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (668 reviews)
"Very nice place to stay ! "
United States
Diana
The price is AU$161
26 July - 27 July
Sheraton Guayaquil Hotel
Terrace/patio

10. Hotel Marcelius

Hotel Marcelius
3.5 star property
Kennedy, 4.7 km from Santa Maria
8.2 out of 10, Very good, (245 reviews)
"All good so far,excellent"
United States
George
The price is AU$92
30 July - 31 July
Hotel Marcelius
Property entrance

11. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 5.2 km from Santa Maria
9.0 out of 10, Wonderful, (644 reviews)
"Nice, clean simple, family run hotel with good transportation."
United States
Gerald
The price is AU$53
2 Aug - 3 Aug
DC Suites Aeropuerto
Front of property

12. Luxva Hotel Boutique

Luxva Hotel Boutique
3.0 star property
Urdesa, 4.7 km from Santa Maria
9.4 out of 10, Exceptional, (181 reviews)
"Love the breakfast menu and security."
United States
Marcela
The price is AU$139
26 July - 27 July
Luxva Hotel Boutique
Terrace/patio

13. Harmonie

Harmonie
2.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (106 reviews)
"Room was spotless, the staff was wonderful and helpful I can’t wait to visit again "
United States
Marco
The price is AU$50
7 Aug - 8 Aug
Harmonie
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers

14. Cedros Inn Boutique Hotel

Cedros Inn Boutique Hotel
3.5 star property
Urdesa, 4.6 km from Santa Maria
8.6 out of 10, Excellent, (92 reviews)
"Staff was very helpful and nice. The property was well kept, and well located"
United States
Jazmin
The price is AU$114
26 July - 27 July
Cedros Inn Boutique Hotel
2 bars/lounges, lobby lounge

15. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.2 out of 10, Wonderful, (1,004 reviews)
"Nice river view, clean room, nice staff and breakfast buffet great!!!"
United States
Nancy
The price is AU$161
22 Aug - 23 Aug
Wyndham Guayaquil Puerto Santa Ana
Children’s activities

16. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 6.9 km from Santa Maria
9.6 out of 10, Exceptional, (1,002 reviews)
"Definitely the best and friendliest Hotel in Guayaquil!"
United States
Josef Walter
The price is AU$138
8 Aug - 9 Aug
Oro Verde Guayaquil
Double Room, 1 Queen Bed, Private Bathroom, Ground Floor | Outdoor pool

17. MundialCity Hotel Guayaquil

MundialCity Hotel Guayaquil
3.0 star property
Simón Bolívar, 5.1 km from Santa Maria
8.4 out of 10, Very good, (174 reviews)
"Room was great and very clean. The staff is amazingly friendly and nice. This will be my go to hotel from now on ."
United States
Gary
The price is AU$64
26 July - 27 July
MundialCity Hotel Guayaquil
Property grounds

18. Hostal Macaw

Hostal Macaw
3.0 star property
Kennedy, 4.6 km from Santa Maria
10.0 out of 10, Exceptional, (10 reviews)
"Very convenient to airport and local shopping. Outstanding service and price."
United States
Scottie
The price is AU$102
26 July - 27 July
Hostal Macaw
Outdoor pool, open 8:00 AM to 9:00 PM, pool loungers

19. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 7.9 km from Santa Maria
9.2 out of 10, Wonderful, (1,004 reviews)
"I enjoyed everything about this hotel."
United States
Maria Dorila
The price is AU$130
8 Aug - 9 Aug
Grand Hotel Guayaquil, Centro Histórico.
Breakfast meal

20. MC Suites

MC Suites
3.5 star property
Kennedy, 4.4 km from Santa Maria
8.2 out of 10, Very good, (138 reviews)
"It is good for a day or 2 close to airport. Clean and staff excellent "
United States
Eulises
The price is AU$65
26 July - 27 July
MC Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Our guide on where to stay in Santa Maria

Find the best Santa Maria areas for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

An iguana on green grass.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Central Market while you're in town.

A densely packed urban area with numerous buildings and a prominent tower on a hill.

Puerto Santa Ana

Restaurants and river views are some things travellers note about Puerto Santa Ana. Check out Santa Ana Hill or Botanical Garden while you're familiarising yourself with the larger area.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area.

A green and yellow iguana on a rocky surface.

Urdesa

Urdesa is well liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to Alban Borja Commercial Center or San Marino Mall.

Top Santa Maria Hotel Reviews

Recent Reviews in Santa Maria

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

8/10 Good
"L’hôtel est bien située près de la rivière."
Annick 1-night trip
Posted 18 hours ago
Wyndham Guayaquil Puerto Santa Ana

Frequently asked questions

When is the best time to go to Santa Maria?
The best time to visit Santa Maria is during the dry season, which runs from May to December, offering pleasant weather for exploring.

During these months, you'll experience less humidity and more sunshine, making it ideal for enjoying outdoor activities and sightseeing. The temperatures are consistently warm but not overly hot, typically ranging from 25°C to 30°C. This period is great for travellers who prefer clear skies and comfortable conditions for their adventures.

For those interested in wildlife, particularly birdwatching, the dry season is especially rewarding as many species are more active and visible.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline − this is often within 24 to 48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our 'Fully refundable property' filter during your search to find the right Santa Maria hotel for you.
How can I save on a hotel booking in Santa Maria with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Santa Maria hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Santa Maria?
Hotel prices in Santa Maria often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates and sort search results by 'Price: low to high' for our cheapest rates.