Santa Maria Hotels, Guayaquil

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Check prices for these dates

Tonight
30 Dec - 31 Dec
Tomorrow
31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

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Our top choices for Santa Maria hotels

Lobby
DC Suites Aeropuerto

DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 5.2 km from Santa Maria
9.0 out of 10, Wonderful, (588)
"Great location and clean hotel"
United States
Elvin
DC Suites Aeropuerto
Outdoor pool
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
5.5 km from Santa Maria
9.4 out of 10, Exceptional, (1009)
"Great stay"
United States
Susan
The price is AU$120
5 Jan - 6 Jan 2026
Holiday Inn Guayaquil Airport by IHG
Children’s activities
Oro Verde Guayaquil

Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 6.9 km from Santa Maria
9.4 out of 10, Exceptional, (1005)
"Great room, excellent breakfast options! "
United States
Francisco
The price is AU$143
1 Jan - 2 Jan 2026
Oro Verde Guayaquil
Exterior
TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1002)
"Wonderful hotel, great service. "
United States
Siamak
The price is AU$136
2 Jan - 3 Jan 2026
TRYP by Wyndham Guayaquil Airport
Habitación cuádruple ejecutiva, dormitorio mixto, baño compartido, vistas a la ciudad (1) | View from room
Villa Celeste - VC

Villa Celeste - VC

Villa Celeste - VC
2.5 star property
9.3 km from Santa Maria
7.4 out of 10, Good, (13)
"It is a good place, they respect your privacity and has a good communication with tourist places "
Mexico
Moises Reque
The price is AU$24
1 Jan - 2 Jan 2026
Villa Celeste - VC
2 restaurants, breakfast, lunch, dinner served; Regional cuisine
Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (606)
"Very friendly front desk thank you for a comfortable and enjoyable stay. "
United States
Andrew
The price is AU$145
30 Jan - 31 Jan 2026
Sheraton Guayaquil Hotel
Interior
Hostal Macaw

Hostal Macaw

Hostal Macaw
3.0 star property
Kennedy, 4.6 km from Santa Maria
10.0 out of 10, Exceptional, (9)
"Wonderful hosts and felt like home "
United States
Tina
The price is AU$106
2 Jan - 3 Jan 2026
Hostal Macaw
Outdoor pool, open 8:00 AM to 9:00 PM, pool loungers
Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel
4.0 star property
Rocafuerte, 7.9 km from Santa Maria
9.2 out of 10, Wonderful, (999)
"Room great & Katlen checked us in with a smile & friendly attitude which was lovely considering how late it was"
United Kingdom
John
The price is AU$128
1 Jan - 2 Jan 2026
Grand Hotel Guayaquil, an Ascend Collection Hotel
Presidential Suite, 1 King Bed, Jetted Tub, River View
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.2 out of 10, Wonderful, (1000)
"Clean rooms,great staff and very good food"
Canada
Abel Patricio
The price is AU$168
4 Jan - 5 Jan 2026
Wyndham Guayaquil Puerto Santa Ana
Lobby lounge
Mansión del Río

Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 7.8 km from Santa Maria
8.8 out of 10, Excellent, (136)
"Breakfast was good. I enjoyed my scrambled eggs and toast "
United States
Caitlin
The price is AU$99
1 Jan - 2 Jan 2026
Mansión del Río
Massages
Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport
4.0 star property
Garzota, 4.8 km from Santa Maria
8.6 out of 10, Excellent, (223)
"Room was modern and clean. It was great they arranged a driver to pick me up at the airport!"
United States
Kenneth
Hotel Puerto Pacifico Guayaquil Airport
Terrace/patio
Harmonie

Harmonie

Harmonie
2.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (82)
"Great staff very friendly Good spot"
Canada
Chelsea
The price is AU$45
2 Jan - 3 Jan 2026
Harmonie
Lobby
Hilton Colon Guayaquil

Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 4.2 km from Santa Maria
8.6 out of 10, Excellent, (825)
"Todo excelente!"
Mexico
Martin
The price is AU$159
25 Jan - 26 Jan 2026
Hilton Colon Guayaquil
Rooftop bar, al fresco dining, open daily
Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (1001)
"Airport shuttle was very convenient "
Canada
Arlene
The price is AU$125
23 Jan - 24 Jan 2026
Wyndham Garden Guayaquil
Exterior
Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast
3.5 star property
2.9 km from Santa Maria
9.2 out of 10, Wonderful, (46)
"Excelente Todo "
Costa Rica
Cesar
The price is AU$84
7 Jan - 8 Jan 2026
Iguanazu Bed & Breakfast
Premium bedding, desk, laptop workspace, iron/ironing board
Hotel La Ria Durán

Hotel La Ria Durán

Hotel La Ria Durán
3.0 star property
9.8 km from Santa Maria
7.2 out of 10, Good, (19)
"Muy buena experiencia"
Ecuador
HERNAN
The price is AU$72
2 Jan - 3 Jan 2026
Hotel La Ria Durán
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers
Cedros Inn Boutique Hotel

Cedros Inn Boutique Hotel

Cedros Inn Boutique Hotel
3.5 star property
Urdesa, 4.6 km from Santa Maria
8.4 out of 10, Very good, (84)
"The staff went above and beyond to accommodate any special needs that we had. The place itself is clean and very beautiful. Great location, near many restaurants (and Chabad). 10/10 recommend booking your stay here. "
United States
Chana
The price is AU$93
2 Jan - 3 Jan 2026
Cedros Inn Boutique Hotel
43-inch flat-screen TV with digital channels, TV, Netflix
Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.4 out of 10, Exceptional, (100)
"The apartment was in a great location and very clean and well maintained."
United States
Rolando
The price is AU$161
10 Jan - 11 Jan 2026
Luxury Suites Riverfront GYE
Restaurant
Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 7.9 km from Santa Maria
10.0 out of 10, Exceptional, (2)
"The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work. "
United States
Richard
The price is AU$388
1 Jan - 2 Jan 2026
Hotel Río Guayas by Art Hotels Ecuador
Suite, Jetted Tub
Hotel Varadero Internacional

Hotel Varadero Internacional

Hotel Varadero Internacional
3.0 star property
Downtown Guayaquil, 6.6 km from Santa Maria
8.0 out of 10, Very good, (62)
"Overall a good place to stay and close to most destinations."
United States
Daniel
Hotel Varadero Internacional
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in Santa Maria

Find the best Santa Maria areas for the activities you enjoy most.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town.

Puerto Santa Ana

Restaurants and river views are some things travellers note about Puerto Santa Ana. Check out Santa Ana Hill or Numa Pompilio Llona Street while you're familiarising yourself with the larger area.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

Urdesa

Urdesa is well liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Top Santa Maria Hotel Reviews

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

10/10 Excellent
"The rooms were very clean, spacious and comfortable. The breakfast was delicious. Lots of different choices."
Brenda 1-night trip
Posted 1 day ago
Holiday Inn Guayaquil Airport by IHG

Frequently asked questions

What is Santa Maria like?
Travellers are sure to enjoy a stay in Guayaquil's Santa Maria neighbourhood.
If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the best deals in Santa Maria.
What can I see and do in this Guayaquil neighbourhood?
Salón de Eventos Rubi, City Mall and Guayaquil Parrot are just a few of the places to visit in and around Santa Maria. La Rotonda Shopping Center and Santa Ana Port are also worth a visit when you're out sightseeing in Guayaquil.