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Our top choices for Santa Ana hotels

Hotel Casa Isabelita

Hotel Casa Isabelita
3.0 star property
Mompos
9.0 out of 10, Wonderful, (2)
"Good price, friendly staff, look location (short walk to the best parts of Mompox), AC in room worked well (Mompox is pretty hot)"
United States
Cormac
Hotel Casa Isabelita

Bioma Boutique Hotel

Bioma Boutique Hotel
3.0 star property
Mompos
9.4 out of 10, Exceptional, (56)
"Restored colonial house, very well appointed."
Mexico
Jorge
Bioma Boutique Hotel

La Gloria Hotel by BespokeColombia

La Gloria Hotel by BespokeColombia
3.5 star property
Mompos
9.6 out of 10, Exceptional, (41)
"Nice staff and rooms. "
United States
Carlos
The price is AU$180
12 Jan - 13 Jan 2026
La Gloria Hotel by BespokeColombia

BOHEMIA HOTEL BOUTIQUE

BOHEMIA HOTEL BOUTIQUE
2.5 star property
Mompos
6.0 out of 10, (2)
"Muy buenas instalaciones. El servicio fue perfecto desde la Gerente del hotel, Lina, como Daniela y Don Juan. Muchas gracias por el servicio"
Colombia
Juan Pablo
The price is AU$153
30 Dec - 31 Dec
BOHEMIA HOTEL BOUTIQUE

Hotel Archangelus

Hotel Archangelus
3.0 star property
Mompos
10.0 out of 10, Exceptional, (1)
"Absolutely delightful! The staff were helpful and pleasant, the room was well appointed, and the breakfast served was delicious. This was my favorite accommodation during my week in Colombia and I highly recommend it."
United States
Andrea
The price is AU$169
15 Jan - 16 Jan 2026
Hotel Archangelus

San Rafael

San Rafael
3.5 star property
Mompos
9.8 out of 10, Exceptional, (21)
"Very good hotel, staff is great and well located"
United States
Richard
The price is AU$180
15 Jan - 16 Jan 2026
San Rafael

Hotel Casa Evan

Hotel Casa Evan
2.0 star property
Mompos
8.0 out of 10, Very good, (1)
Hotel Casa Evan

LITERATIUM

LITERATIUM
3.0 star property
Mompos
9.0 out of 10, Wonderful, (12)
"The rooms are comfortable and beautiful again."
United States
Emilio
Travelling for leisure
The price is AU$125
17 Jan - 18 Jan 2026
LITERATIUM

La Casa Amarilla

La Casa Amarilla
3.0 star property
Mompos
8.8 out of 10, Excellent, (46)
"Very nice hotel"
Mexico
Jorge
The price is AU$117
16 Jan - 17 Jan 2026
La Casa Amarilla

Hotel Rio Grande

Hotel Rio Grande
3.0 star property
Magangué
The price is AU$54
30 Dec - 31 Dec
Hotel Rio Grande

Hotel Jardines Evans By Geh Suites

Hotel Jardines Evans By Geh Suites
3.0 star property
Mompos
4.0 out of 10, (1)
"Hotel modesto, personal muy amable, pero MUY CARO por lo que ofrece, "
Colombia
enric
Hotel Jardines Evans By Geh Suites

LA CANDELARIA ROOM HOUSE

LA CANDELARIA ROOM HOUSE
3.0 star property
Magangué
The price is AU$48
3 Jan - 4 Jan 2026
LA CANDELARIA ROOM HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Where is the best place to stay in Santa Ana?
LITERATIUM, located 17.9 mi (28.8 km) from the heart of Santa Ana, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Portal de la Marquesa and La Casa Amarilla. See all available top hotels, or vacation rentals in Santa Ana.
What are some of the best holiday rentals that Santa Ana has to offer?
Encantador Apartamento Diseñado Para ti!: This holiday home rental outside of Santa Ana has air conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. See all vacation rentals in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Ana.
What's it like to stay in Santa Ana?
Visitors will definitely enjoy all that Santa Ana has to offer. There are 32 hotels and other accommodation options in the surrounding area. Find out more about Santa Ana.
What should I do while I'm visiting Santa Ana?
A favourite place to visit is Magdalena River. You'll also find Bolívar Stone and Te Deum House in the area. Take a look at what more there is to see and do in Expedia's Santa Ana guide.
What's the seasonal weather like in Santa Ana?
The hottest months are usually February and March, with an average temperature of 29°C, while the coldest months are November and December, with an average of 27°C. The rainiest months in Santa Ana are May, August, October and September, with each month seeing an average of 346 mm of rainfall.