Sanctuary Hotels, Sanibel
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Tonight
Tomorrow
This weekend
Next weekend
Our top choices for Sanctuary hotels
1. Tween Waters Island Resort & Spa
Tween Waters Island Resort & Spa3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,004 reviews)
"We had an amazing time!"
Taylor
The price is AU$495
includes taxes & fees
2 Aug - 3 Aug
2. Sanibel Island Beach Resort
Sanibel Island Beach ResortMid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,129 reviews)
"Great access to beach and rooms very clean!"
Karla
The price is AU$325
includes taxes & fees
17 Aug - 18 Aug
3. Island Inn
Island InnWest End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,139 reviews)
"The place was amazing and the host was very gracious."
Wendy
The price is AU$413
includes taxes & fees
3 Aug - 4 Aug
4. Off the Charts Inn & Out Island Resort
Off the Charts Inn & Out Island Resort8.8 km from Sanctuary
9.6 out of 10, Exceptional, (162 reviews)
"Great little place. Could see the manatees from the dock. Super clean."
Greg
The price is AU$302
includes taxes & fees
3 Aug - 4 Aug
5. Shalimar Beach Resort
Shalimar Beach ResortWest End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (70 reviews)
"Beautiful place! Would definitely stay again."
Vickie
The price is AU$386
includes taxes & fees
17 Aug - 18 Aug
6. South Seas
South Seas5.5 km from Sanctuary
8.4 out of 10, Very good, (1,001 reviews)
"Our family loved our stay! It was so close to all the wonderful aspects of Captiva and we could walk with our younger children to everything. We will definitely be making this a regular vacation spot!"
Erin
The price is AU$576
includes taxes & fees
4 Aug - 5 Aug
7. Residence Inn by Marriott Fort Myers Sanibel
Residence Inn by Marriott Fort Myers Sanibel19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Spacious accommodation, comfortable beds, great staff, great location close to both Fort Myers and Sanibel, and good breakfast. We truly enjoyed our stay and will probably stay there again."
Catherine
The price is AU$143
includes taxes & fees
2 Aug - 3 Aug
8. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,005 reviews)
"Clean room , good breakfast"
Celia
The price is AU$130
includes taxes & fees
6 Aug - 7 Aug
9. Marriott Sanibel Harbour Resort & Spa
Marriott Sanibel Harbour Resort & Spa15.6 km from Sanctuary
8.6 out of 10, Excellent, (1,005 reviews)
"Love the hospitality especially the Valet staff. Onsite food and service was great!!I will definitely recommend and stay at this site again in the future."
Kathryne
The price is AU$355
includes taxes & fees
20 Aug - 21 Aug
10. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway19.9 km from Sanctuary
8.2 out of 10, Very good, (1,276 reviews)
"Clean room, helpful staff an good breakfast"
ALICIA
The price is AU$116
includes taxes & fees
4 Aug - 5 Aug
11. Matlacha on Shoreview
Matlacha on Shoreview20.2 km from Sanctuary
9.6 out of 10, Exceptional, (278 reviews)
"I enjoyed the nature , the ocean, the commodities of the place, the quiet environment, the professional attention from the management, most of all from Stacy's attention, exceptional!!!
Definitely a good sum to the place!!!
If I have to rate her I definitely put a ⭐⭐⭐⭐⭐
For sure, we will be back!!!"
Vilma
The price is AU$223
includes taxes & fees
24 July - 25 July
12. The Anchor Inn
The Anchor InnMid Island, 12.8 km from Sanctuary
9.8 out of 10, Exceptional, (57 reviews)
"Loved staying here, very clean"
Liliana
The price is AU$327
includes taxes & fees
16 Aug - 17 Aug
13. The Westin Cape Coral Resort At Marina Village
The Westin Cape Coral Resort At Marina Village18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1,002 reviews)
"Very nice hotel , beautiful location, lots of amenities"
Marlies
The price is AU$290
includes taxes & fees
9 Aug - 10 Aug
14. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Great hotel"
Cynthia
The price is AU$141
includes taxes & fees
10 Aug - 11 Aug
15. Tarpon Tale Inn
Tarpon Tale InnEast End, 14.8 km from Sanctuary
9.6 out of 10, Exceptional, (408 reviews)
"Owner is really friendly room is very clean nice place."
Daniel
The price is AU$373
includes taxes & fees
28 July - 29 July
16. Kona Kai Motel
Kona Kai MotelMid Island, 12.2 km from Sanctuary
9.0 out of 10, Wonderful, (1,001 reviews)
"Great place to stay and the staff was very helpful"
Gregory John
The price is AU$265
includes taxes & fees
28 July - 29 July
17. Angler's Inn
Angler's Inn18.8 km from Sanctuary
9.4 out of 10, Exceptional, (335 reviews)
"Just a great Air B&B in a small fishing village .perfect stay and we will definitely return."
Paul
The price is AU$247
includes taxes & fees
22 July - 23 July
18. Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Holiday Inn Express Cape Coral-Fort Myers Area by IHG23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,588 reviews)
"Staff is very friendly and helpful"
Mark
The price is AU$161
includes taxes & fees
9 Aug - 10 Aug
19. Latitude 26 Waterfront Resort & Marina
Latitude 26 Waterfront Resort & Marina22 km from Sanctuary
8.6 out of 10, Excellent, (1,003 reviews)
"Excellent service, we really enjoyed it, even though it was only one night I was very pleased"
Jaroslava
The price is AU$168
includes taxes & fees
22 July - 23 July
20. Candlewood Suites Fort Myers Sanibel Gateway by IHG
Candlewood Suites Fort Myers Sanibel Gateway by IHG25.4 km from Sanctuary
7.6 out of 10, Good, (1,002 reviews)
"Everything was great and easy to get everywhere"
Sheri Lea
The price is AU$88
includes taxes & fees
28 July - 29 July
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Sanctuary
Find the best Sanctuary areas for the activities you enjoy most.
Mid Island
If you're spending some time in Mid Island, Sanibel Island Southern Beach and Periwinkle Way are top sights worth seeing.
West End
If you're spending some time in West End, Sanibel Island Southern Beach and J. N. Ding Darling National Wildlife Refuge are top sights worth seeing.
East End
While visiting East End, you might make a stop by sights like Sanibel Island Southern Beach and Sanibel Island Northern Beach.
Beachview Country Club Estates
While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.
Gulf Shores
When in Gulf Shores, you can plan a visit to Bowman's Beach and J. N. Ding Darling National Wildlife Refuge, some noteworthy sights in the nearby area.
Frequently asked questions
Explore a world of travel with Expedia
- Bonita Springs Home Private Pool & Backyard 5 minutes to the Beach and Boulevard
- Bonita Springs Hotels
- Beach House
- Lgbt Welcoming Hotels in Cape Coral
- Sand By Me
- Hurricane Windows Pool
- Turtle’s COVE offers a bright and refreshing oasis in sunny
- Vida Del Agua
- Villa CORAL ESCAPE – HEATED POOL & SPA
- Villa Juhara
- Vrcc Villa Lena
- Plantation Beach Club at South Seas Island Resort
- Beautiful Bay Views&Sunsets 2/2Walk to beach/ Pets
- ⛱️Canal Front Penthouse
- Fabulous Beach Front Condo Unit 314 with Amazing View of the Gulf of Mexico
- Fort Myers Beachfront Condo Mojito Villas 1BR Near Time Square & Bowditch Park
- Lgbt Welcoming Hotels in Fort Myers Beach
- 🏖️Private Pool with Backyard Oasis
- Mermaid
- The Seashell at Fort Myers Beach Inn
- Villa Capri · 2025 Luxury Build · Steps to Beach
- Bridgewater Inn
- Casa Ybel Resort
- Diamondhead Beach Resort
- Dolphin Key Resort
- Minutes to the beach!
- Pink Shell Beach Resort and Marina
- The Lighthouse Resort Inn & Suites
- The Little Oasis Beach House
- Latitude 26 Waterfront Resort & Marina
- Fort Myers Hotels
- Golden Gate Hotels
- Hilton Hotels in Manasota Key
- Marco Island Hotels
- Lgbt Welcoming Hotels in Mediterra
- Apartments in Naples
- Beach Hotels in Naples
- Doubletree Suites by Hilton Naples
- Greenlinks Golf Villas at Lely Resort
- * The 96 *
- The CLARIDGE 17D
- Special Offer! Limited
- Waterlily at Greenlinks
- Naples Hotels
- Old Naples Hotels
- Osprey Hotels
- B&B in Pine Ridge
- Little Gasparilla Island
- Baymont by Wyndham Punta Gorda/Port Charlotte
- Punta Gorda Waterfront Hotel and Suites
- Wyvern Hotel
- 2
- Casa Del Kona South
- 65' Yacht Escape on Private Canal. Fish & Kayak. Support InclusiveInc.org
- Sunseeker Resort Florida Gulf Coast
- Beautiful home with great water and golf views!
- Coastal ACCENTS AND CHARM
- Bright and breezy poolside escape on Sanibel Island
- Have a Shelluva Time at this 3br/2.5ba near beach ground level pool home. Pup friendly and perfect for stargazing!
- Seahorse Suites #4. A Perfect Beach Getaway!
- Stunning new Seashells 6
- Relax in Peaceful Paradise Directly on the Beach
- Whispering Palms
- Flights to Fort Myers
- Flights to Naples
- Flights to Pine Island
- Flights to Punta Gorda
- Flights from Southwest Florida Intl.
- Flights from Sanibel Captiva Island
- Flights from Punta Gorda
- Flights from Brisbane (BNE) to Fort Myers (RSW)
- Flights from Boston (BOS) to Fort Myers (RSW)
- Flights from Dallas (DFW) to Fort Myers (RSW)
- Flights from Fort Lauderdale (FLL) to Fort Myers (RSW)
- Flights from Hobart (HBA) to Fort Myers (RSW)
- Flights from Houston (HOU) to Fort Myers (RSW)
- Flights from Los Angeles (LAX) to Fort Myers (RSW)
- Flights from Melbourne (MEL) to Fort Myers (RSW)
- Flights from Miami (MIA) to Fort Myers (RSW)
- Flights from Melbourne (MLB) to Fort Myers (RSW)
- Flights from Perth (PER) to Fort Myers (RSW)
- Flights from Pensacola (PNS) to Fort Myers (RSW)
- Flights from Sydney (SYD) to Fort Myers (RSW)