San Francisco Holidays

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Your San Francisco Holiday

From its highlights to its hidden treasures, this city is best experienced with a San Francisco holiday package. Find a place to stay in El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes. Every trip to San Francisco needs a well-designed itinerary. Fill yours with famous sights like Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. Your ideal San Francisco holiday is only clicks away. Browse airfares, hotels and more on Expedia for a getaway that's tailored just for you.

Our guide on where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
View of the Panama City Old Town

Casco Viejo

5/5(2 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Our pick of the best San Francisco Hotel Deals

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is AU$207 per night from 15 Mar to 16 Mar
AU$207
15 Mar - 16 Mar
includes taxes & fees
8.6/10 Excellent! (1,003 reviews)
Helpful staff. Clean room

Reviewed on 28 Feb 2026

Sheraton Grand Panama
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
The price is AU$246 per night from 1 Apr to 2 Apr
AU$246
1 Apr - 2 Apr
includes taxes & fees
9/10 Wonderful! (1,004 reviews)
Courteous staff. Lovely property

Reviewed on 1 Mar 2026

Las Americas Golden Tower Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
The price is AU$380 per night from 2 Apr to 3 Apr
AU$380
2 Apr - 3 Apr
includes taxes & fees
9/10 Wonderful! (1,001 reviews)
Great breakfast, service cleanliness.

Reviewed on 21 Feb 2026

JW Marriott Panama
See all 1,574 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
All Inclusive Holidays
Cheap Holidays
Cheap Holidays
Cheap Holidays
beach holidays
Beach Holidays
Beach Holidays

Frequently asked questions

How much does a San Francisco holiday package cost?
Much less than you might think — from a low , in fact! By bundling hotels, flights and car rentals into a custom-built holiday package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco holiday package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes travelling on the cheap easy. And with more than 550 partner airlines and 1 000 000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Centre. Ph Boutique Quartier Atlapa or New Cosy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travellers.
How far in advance should I book my San Francisco holiday?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco holiday looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia holiday package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco holiday package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco holiday package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Discover the most popular places to visit in San Francisco

Rainy day in Panama City but the charm of this city never ends. A beautiful rainbow over the city invites us to spend a bright day in paradise. #LifeAtExpedia

Multiplaza Pacific Mall

During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall

Activities

Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

AU$69
per adult
100% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
The Panama Barcrawl - The OG Crawl

The Panama Barcrawl - The OG Crawl (Panama City, Panama)

AU$92
per adult
100% of travellers recommend
The Panama Barcrawl - The OG Crawl (Panama City, Panama)
Boat tour in the Panama Canal to Monkeys and sloths islands

Boat tour in the Panama Canal to Monkeys and sloths islands

AU$105
per adult
100% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.