
San Francisco Holidays
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Your San Francisco Holiday
From its highlights to its hidden treasures, this city is best experienced with a San Francisco holiday package. Find a place to stay in El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes. Every trip to San Francisco needs a well-designed itinerary. Fill yours with famous sights like Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. Your ideal San Francisco holiday is only clicks away. Browse airfares, hotels and more on Expedia for a getaway that's tailored just for you.
Our guide on where to stay in San Francisco

Casco Viejo
Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.
Our pick of the best San Francisco Hotel Deals

Las Americas Golden Tower Panama
Going location, great city views
Reviewed on 4 Jan 2026

Megapolis Hotel Panamá
The vibes and the view
Reviewed on 11 Jan 2026

Plaza Paitilla Inn Hotel
Execellent ad aiesys
Reviewed on 12 Jan 2026
Frequently asked questions
Discover the most popular places to visit in San Francisco

Multiplaza Pacific Mall
During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Activities

Boat tour in the Panama Canal to Monkeys and sloths islands













