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Top hotels and accommodation in San Francisco

Hotel Gran David

3.5 star property
Santiago
8.6 out of 10, Excellent, (352)
"Nice hotel with beautiful interior gardens which make you feel like being in one big hacienda."
United States
Anne Gesine
Travelling with partner
Hotel Gran David

Hotel Galería

3.0 star property
Nuevo Santiago
8.4 out of 10, Very good, (205)
"Everything was nice!"
United States
Daniel
The price is AU$106
includes taxes & fees
7 Dec - 8 Dec
Hotel Galería

Hotel Mykonos Panama

3.5 star property
Nuevo Santiago
8.8 out of 10, Excellent, (536)
"Great place to stay for a stop over , conveniently located off the highway and close to shopping areas"
United States
Andy
Travelling with family
The price is AU$141
includes taxes & fees
7 Dec - 8 Dec
Hotel Mykonos Panama

HOTEL VISTA LAGO

3.0 star property
La Pena
9.2 out of 10, Wonderful, (78)
"An oasis with a lagoon with birds and a great pool."
United States
Maria
Travelling with family
The price is AU$118
includes taxes & fees
6 Jan - 7 Jan 2026
HOTEL VISTA LAGO

Hotel Anachoreo

3.0 star property
Santa Fe
9.4 out of 10, Exceptional, (35)
"Wonderful place at a beautiful stay . I can recommend it totally ! "
United States
Ingmar
Hotel Anachoreo

La Qhia Eco Retreat

2.5 star property
Santa Fe
8.0 out of 10, Very good, (18)
"Very noisy due to neighbouring roosters & dogs at night. Food good & easy access. "
Canada
Heather
La Qhia Eco Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What's the best place for a stay in San Francisco?
Hotel Gran David, located 9.5 mi (15.4 km) from the heart of San Francisco, is a top choice for your stay, based on our traveller data. Other good options for your stay in the area are Hotel Mykonos Panama and HOTEL VISTA LAGO. See all available top hotels, or vacation rentals in San Francisco.
What are some of the best holiday rentals that San Francisco has to offer?
Cabana Vergara Santa Fe: This holiday home rental outside of San Francisco offers a patio, a garden and air conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop and a coffee maker. See all vacation rentals in San Francisco.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in San Francisco.
What is staying in San Francisco like?
Visitors to San Francisco will definitely find plenty to explore and enjoy. There are 17 hotels and other accommodation options in the surrounding area. Find out more about San Francisco.
What should I see while I'm in San Francisco?
Places to visit in the wider area include Laguna de La Yeguada, Los Pozos Termales and Parque Acuatico Italia Guadalupe Panama. You'll also find Omar Torrijos Herrera Stadium and Plaza Banconal in the area. Take a look at what more there is to see and do in Expedia's San Francisco guide.
What's the seasonal weather like in San Francisco?
The hottest months are usually March and April, with an average temperature of 27°C, while the coldest months are January and December, with an average of 25°C. The rainiest months in San Francisco are October, August, June and November, with each month seeing an average of 447 mm of rainfall.