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Check prices for these dates

This weekend
3 July - 5 July
Next weekend
10 July - 12 July

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Our top choices for Puxico hotels

Lobby

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,002 reviews)
"Great place to stay. Clean, great staff and the food is good. Would stay again."
United States
Stephanie
The price is AU$153
includes taxes & fees
19 July - 20 July
Drury Inn & Suites Poplar Bluff
Free daily buffet breakfast

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (885 reviews)
"Nice quiet overnight stay."
United States
Tammy
The price is AU$159
includes taxes & fees
26 July - 27 July
Hampton Inn Poplar Bluff
Coffee service

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,002 reviews)
"Clean room and convenient location."
United States
Morgan
The price is AU$128
includes taxes & fees
8 July - 9 July
Motel 6 Poplar Bluff, MO
Lobby

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (929 reviews)
"Hotel Staff was very friendly!"
United States
Alice
The price is AU$165
includes taxes & fees
2 Aug - 3 Aug
Fairfield Inn & Suites by Marriott Poplar Bluff
Lobby sitting area

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (101 reviews)
"It was a very neat experience! Highly recommend you stop here and get away from big chain hotels for a night. The staff were super friendly and the restaurant/store was so nostalgic!"
United States
DANIELLE
The price is AU$141
includes taxes & fees
4 July - 5 July
EC Reed's Mercantile and Hotel
Lobby

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.8 out of 10, Exceptional, (42 reviews)
"Great place to stay"
United States
Lauren
The price is AU$170
includes taxes & fees
19 July - 20 July
Hampton Inn By Hilton Dexter
In-room safe, desk, free WiFi, bed sheets

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (654 reviews)
"Easy to check in"
United States
Aisa
The price is AU$111
includes taxes & fees
11 July - 12 July
Super 8 by Wyndham Poplar Bluff Missouri
Lobby

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (422 reviews)
"Chad the manager was great getting my family on same floor and close together. The breakfast was very good. Only things negative is needed replace towels in the morning and when clean the room for next person clean under the bed"
United States
jeannie
The price is AU$144
includes taxes & fees
2 Aug - 3 Aug
Comfort Inn Poplar Bluff North
Front of property

Lake Wappapello

Lake Wappapello
2.0 star property
Williamsville
8.8 out of 10, Excellent, (3 reviews)
"Pet friendly. Family-friendly "
United States
Tonya
The price is AU$117
includes taxes & fees
21 July - 22 July
Lake Wappapello
Breakfast, lunch and dinner served

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (749 reviews)
"Great staff especially Ms Wilma at the front desk!"
United States
Denise
The price is AU$152
includes taxes & fees
2 Aug - 3 Aug
Holiday Inn Poplar Bluff by IHG
Breakfast area

Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (353 reviews)
"Nice rooms, friendly staff, "
United States
Sarah
The price is AU$97
includes taxes & fees
27 July - 28 July
Dexter Inn
Breakfast, lunch and dinner served

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (413 reviews)
"Clean room, staff was super helpful"
United States
Katherine
The price is AU$146
includes taxes & fees
5 July - 6 July
Travelodge by Wyndham Dexter
Desk, iron/ironing board, free WiFi, bed sheets

OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (139 reviews)
"Loved the room "
United States
Jessica
The price is AU$85
includes taxes & fees
1 Aug - 2 Aug
OYO Hickory House Inn
Desk, iron/ironing board, free WiFi, bed sheets

Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (270 reviews)
"Air was not cold, bathroom door did not close, not a good selection for breakfast"
United States
Amanda
The price is AU$83
includes taxes & fees
2 Aug - 3 Aug
Econo Lodge Dexter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Puxico

Head to sights like Mark Twain National Forest and Mingo Wilderness as you discover Puxico.

See all hotels in Puxico
A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

Recent Reviews in Puxico

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Breakfast was great. Staff always nice."
Megan 1-night trip
Posted 8 hours ago
Drury Inn & Suites Poplar Bluff

More cheap accommodation in Puxico

Econo Lodge Dexter

Econo Lodge Dexter

913 Outer Rd Dexter MO
The price is AU$83 per night from 2 Aug to 3 Aug
AU$83
2 Aug - 3 Aug
includes taxes & fees
6.8/10 (270 reviews)

Frequently asked questions

What's the best place for a stay in Puxico?
Motel 6 Poplar Bluff, MO, located 19.4 mi (31.3 km) from the heart of Puxico, is a top choice for your stay, based on our traveller data. Other good options for your trip to the area are Fairfield Inn & Suites by Marriott Poplar Bluff and Hampton Inn Poplar Bluff. See all available top hotels, or vacation rentals in Puxico.
What are some of the best holiday rentals that Puxico has to offer?
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy: This holiday home rental outside of Puxico offers a fireplace, a balcony and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You can relax into your holiday with a garden and a selection of games. See all vacation rentals in Puxico.
If I need to cancel my hotel reservation in Puxico, will I receive a refund?
Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.
What is staying in Puxico like?
Travellers to Puxico will find plenty to explore and enjoy. There are 54 hotels and other accommodation options in the surrounding area. Find out more about Puxico.
What is there to see in Puxico?
A couple of favourite places to visit are Mark Twain National Forest and Mingo Wilderness. You'll also find Lake Wappapello and Lake Wappapello State Park in the area. Take a look at what more there is to see and do in Expedia's Puxico guide.
What's the seasonal weather in Puxico?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Puxico is 1502 mm.