Search O Brien hotels

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
19 Oct - 20 Oct
Tomorrow
20 Oct - 21 Oct
Next weekend
24 Oct - 26 Oct
In two weeks
31 Oct - 2 Nov

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in O Brien

Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
9.4 out of 10, Exceptional, (1016)
"Clean rooms, helpful staff, great breakfast"
United States
Bambi
The price is AU$211
includes taxes & fees
21 Oct - 22 Oct
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Desk, blackout curtains, iron/ironing board, rollaway beds
Americas Best Value Inn Alachua
Americas Best Value Inn Alachua
2.0 star property
4.8 out of 10, (588)
"Staff very helpful and property clean"
United States
Donna
The price is AU$116
includes taxes & fees
20 Oct - 21 Oct
Americas Best Value Inn Alachua
Breakfast area
Hampton Inn & Suites Alachua I-75
Hampton Inn & Suites Alachua I-75
2.5 star property
9.4 out of 10, Exceptional, (461)
"Great staff"
United States
Brooke Olden
The price is AU$208
includes taxes & fees
28 Oct - 29 Oct
Hampton Inn & Suites Alachua I-75
Exterior
La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
8.8 out of 10, Excellent, (1019)
"We have stayed here multiple times, always convenient and our choice when passing through Lake City "
United States
Christopher
The price is AU$162
includes taxes & fees
9 Nov - 10 Nov
La Quinta Inn & Suite by Wyndham Lake City
Double Room, Non Smoking
High Springs Country Inn
High Springs Country Inn
2.0 star property
8.6 out of 10, Excellent, (12)
"Great remodel of a retro motel."
United States
Kathleen
The price is AU$114
includes taxes & fees
21 Oct - 22 Oct
High Springs Country Inn
Lobby
Best Western Plus Lake City
Best Western Plus Lake City
2.5 star property
9.2 out of 10, Wonderful, (1026)
"Good breakfast, very clean room, great decor and overall a nice play to stay."
United States
Francisco
The price is AU$140
includes taxes & fees
2 Nov - 3 Nov
Best Western Plus Lake City
Fireplace
Courtyard By Marriott Lake City
Courtyard By Marriott Lake City
3.0 star property
9.6 out of 10, Exceptional, (154)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
The price is AU$189
includes taxes & fees
26 Oct - 27 Oct
Courtyard By Marriott Lake City
Pillow-top beds, desk, laptop workspace, iron/ironing board
Comfort Suites Lake City
Comfort Suites Lake City
2.5 star property
9.6 out of 10, Exceptional, (1010)
"We love to stop here when traveling to Orlando"
United States
Bridget
The price is AU$167
includes taxes & fees
16 Nov - 17 Nov
Comfort Suites Lake City
Standard Cabin, 1 Queen Bed | Exterior
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
2.0 star property
10.0 out of 10, Exceptional, (126)
"Great place "
United States
Joey
The price is AU$286
includes taxes & fees
20 Oct - 21 Oct
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Outdoor pool
Baymont by Wyndham Lake City I-75
Baymont by Wyndham Lake City I-75
2.5 star property
5.0 out of 10, (1011)
"Just a perfect place to take a break while traveling. Clean,comfortable and a great staff. "
United States
Cris
The price is AU$100
includes taxes & fees
26 Oct - 27 Oct
Baymont by Wyndham Lake City I-75
Outdoor pool, pool loungers
Quality Inn Lake City
Quality Inn Lake City
2.5 star property
7.8 out of 10, Good, (935)
"Very nice place, would definitely stay there again!"
United States
Gerald
The price is AU$138
includes taxes & fees
17 Nov - 18 Nov
Quality Inn Lake City
Individually decorated, desk, laptop workspace, iron/ironing board
Days Inn by Wyndham Lake City I-10
Days Inn by Wyndham Lake City I-10
2.0 star property
6.8 out of 10, (1001)
"All was good. Staff was great."
United States
Janice
The price is AU$97
includes taxes & fees
20 Oct - 21 Oct
Days Inn by Wyndham Lake City I-10
Exterior
Tru by Hilton Lake City
Tru by Hilton Lake City
2.5 star property
9.2 out of 10, Wonderful, (1013)
"Good hotel"
United States
Frank
The price is AU$189
includes taxes & fees
26 Oct - 27 Oct
Tru by Hilton Lake City
Standard Room, 2 Queen Beds, Non Smoking
Quality Inn White Springs Suwanee
Quality Inn White Springs Suwanee
2.5 star property
7.2 out of 10, Good, (592)
"Clean room Friendly staff"
United States
Lloyd
The price is AU$115
includes taxes & fees
3 Nov - 4 Nov
Quality Inn White Springs Suwanee
BBQ/picnic Area
Americas Best Value Inn Lake City
Americas Best Value Inn Lake City
2.0 star property
8.8 out of 10, Excellent, (1002)
"Great people, nice place."
United States
Daniel
The price is AU$117
includes taxes & fees
21 Oct - 22 Oct
Americas Best Value Inn Lake City
Lobby
Fairfield Inn & Suites Lake City
Fairfield Inn & Suites Lake City
2.5 star property
9.0 out of 10, Wonderful, (135)
"Friendly staff"
United States
Zohar
The price is AU$154
includes taxes & fees
27 Oct - 28 Oct
Fairfield Inn & Suites Lake City
Lobby
Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake City
2.5 star property
9.4 out of 10, Exceptional, (1015)
"It was a great stay "
United States
Miranda
The price is AU$166
includes taxes & fees
26 Oct - 27 Oct
Hampton Inn & Suites Lake City
Reception
BlueGem Motel
BlueGem Motel
2.0 star property
9.2 out of 10, Wonderful, (377)
"Great place to stay."
United States
Wesley
The price is AU$160
includes taxes & fees
22 Oct - 23 Oct
BlueGem Motel
Pillow-top beds, in-room safe, desk, blackout curtains
Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75
2.0 star property
7.4 out of 10, Good, (1010)
"The staff was nice and check in was easy"
United States
Crystal
The price is AU$116
includes taxes & fees
9 Nov - 10 Nov
Days Inn by Wyndham Lake City I-75
Exterior
Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake City
2.0 star property
7.2 out of 10, Good, (649)
"Very friendly staff, delicious breakfast and dinner, clean pool, spacious room. Best hotel in the last 4 years within same price range"
United States
Marina
The price is AU$116
includes taxes & fees
21 Oct - 22 Oct
Super 8 by Wyndham Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
Photo by Dr__Vlad
Open Photo by Dr__Vlad

Top O Brien Hotel Reviews

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

10/10 Excellent
"Clean, simple, and exactly what I needed! Staff was super kind and helpful. Only slight complaint is it seemed the noise was sneaking through the door of my road-facing room, but it didn’t bother me once I went to bed."
Carl 1-night trip
Posted 2 days ago
Americas Best Value Inn Lake City

More cheap accommodation in O Brien

Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr, Lake City, FL
The price is AU$140 per night from 2 Nov to 3 Nov
AU$140
2 Nov - 3 Nov
includes taxes & fees
9/10 Wonderful! (1,026 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Best Western Plus Lake City and Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Walking distance to Brewery and Restaurants ⭐️⭐️⭐️⭐️⭐️: This holiday home rental outside of O Brien is located on a river, and has a fireplace, a patio and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. Make the most of games in this rental home to help you unwind. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Features buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Best Western Plus Lake City and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia