Search O Brien hotels

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
4 Sept - 5 Sept
Tomorrow
5 Sept - 6 Sept
This weekend
5 Sept - 7 Sept
Next weekend
12 Sept - 14 Sept

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in O Brien

Our top choices for O Brien hotels

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
9.4 out of 10, Exceptional, (1002)
"Great place to stay plus so clean-up, breakfast very delicius!!!!"
The price is AU$186
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Americas Best Value Inn Alachua
Desk, blackout curtains, iron/ironing board, rollaway beds

Americas Best Value Inn Alachua

2.0 star property
4.8 out of 10, (576)
"Good people that work there."
The price is AU$110
includes taxes & fees
9 Sept - 10 Sept
Americas Best Value Inn Alachua
Hampton Inn & Suites Alachua I-75
Breakfast area

Hampton Inn & Suites Alachua I-75

2.5 star property
9.4 out of 10, Exceptional, (449)
"Friendly staff, bed was comfortable "
The price is AU$186
includes taxes & fees
11 Sept - 12 Sept
Hampton Inn & Suites Alachua I-75
High Springs Country Inn
Double Room, Non Smoking

High Springs Country Inn

2.0 star property
8.0 out of 10, Very good, (6)
"Ive had a stay at this price point with better arrangement such as breakfast included. However, for only one night it wasnt too bad. Room is too dark. Lighter colors in the room luke greish would make it look more cozy."
The price is AU$106
includes taxes & fees
22 Sept - 23 Sept
High Springs Country Inn
La Quinta Inn & Suite by Wyndham Lake City
Exterior

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
8.8 out of 10, Excellent, (1000)
"Very good stay"
The price is AU$170
includes taxes & fees
10 Sept - 11 Sept
La Quinta Inn & Suite by Wyndham Lake City
Courtyard By Marriott Lake City
Fireplace

Courtyard By Marriott Lake City

3.0 star property
9.6 out of 10, Exceptional, (134)
"Great hotel "
The price is AU$165
includes taxes & fees
5 Oct - 6 Oct
Courtyard By Marriott Lake City
Best Western Plus Lake City
Lobby

Best Western Plus Lake City

2.5 star property
9.2 out of 10, Wonderful, (1017)
"The staff was all very friendly, room was clean and beds were comfortable."
The price is AU$132
includes taxes & fees
10 Sept - 11 Sept
Best Western Plus Lake City
Comfort Suites Lake City
Lobby

Comfort Suites Lake City

2.5 star property
9.6 out of 10, Exceptional, (1001)
"Amazing place to stay"
The price is AU$181
includes taxes & fees
14 Sept - 15 Sept
Comfort Suites Lake City
Quality Inn Lake City
Outdoor pool, pool loungers

Quality Inn Lake City

2.5 star property
7.8 out of 10, Good, (920)
"Great location right off the interstate"
The price is AU$130
includes taxes & fees
5 Oct - 6 Oct
Quality Inn Lake City
Baymont by Wyndham Lake City
Outdoor pool

Baymont by Wyndham Lake City

2.5 star property
5.0 out of 10, (1001)
"Breakfast was okay and rooms were dirty "
The price is AU$99
includes taxes & fees
9 Sept - 10 Sept
Baymont by Wyndham Lake City
Tru by Hilton Lake City
Exterior

Tru by Hilton Lake City

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Staff was friendly, hotel was clean and close to resturants in the area."
The price is AU$171
includes taxes & fees
14 Sept - 15 Sept
Tru by Hilton Lake City
Hampton Inn & Suites Lake City
Lobby

Hampton Inn & Suites Lake City

2.5 star property
9.4 out of 10, Exceptional, (1002)
"Conveniently located near many restaurants & stores. "
The price is AU$187
includes taxes & fees
28 Sept - 29 Sept
Hampton Inn & Suites Lake City
Postcard Cabins Gilchrist Springs
Exterior

Postcard Cabins Gilchrist Springs

2.0 star property
10.0 out of 10, Exceptional, (95)
"Beautiful cabin and stay "
The price is AU$225
includes taxes & fees
8 Sept - 9 Sept
Postcard Cabins Gilchrist Springs
Days Inn by Wyndham Lake City I-10
Free daily on-the-go breakfast

Days Inn by Wyndham Lake City I-10

2.0 star property
6.8 out of 10, (1001)
"It s a very nice hotel"
The price is AU$110
includes taxes & fees
14 Sept - 15 Sept
Days Inn by Wyndham Lake City I-10
Guest Inn
Reception

Guest Inn

2.0 star property
6.0 out of 10, (187)
"👍"
Guest Inn
Fairfield Inn & Suites Lake City
Lobby lounge

Fairfield Inn & Suites Lake City

2.5 star property
9.0 out of 10, Wonderful, (124)
"Friendly staff"
The price is AU$179
includes taxes & fees
21 Sept - 22 Sept
Fairfield Inn & Suites Lake City
Quality Inn White Springs Suwanee
Standard Room, 2 Queen Beds, Non Smoking

Quality Inn White Springs Suwanee

2.5 star property
7.2 out of 10, Good, (575)
"it was just quiet and conveient for me.. Let Sarah and crew know that they did a great job and would love to stay again.."
The price is AU$107
includes taxes & fees
14 Sept - 15 Sept
Quality Inn White Springs Suwanee
BlueGem Motel
Reception

BlueGem Motel

2.0 star property
9.2 out of 10, Wonderful, (368)
"Great place to stay."
The price is AU$142
includes taxes & fees
9 Sept - 10 Sept
BlueGem Motel
Americas Best Value Inn Lake City
BBQ/picnic area

Americas Best Value Inn Lake City

2.0 star property
8.8 out of 10, Excellent, (1002)
"Awesome staff and very clean rooms "
The price is AU$122
includes taxes & fees
9 Sept - 10 Sept
Americas Best Value Inn Lake City
Holiday Inn & Suites Lake City by IHG
Exterior

Holiday Inn & Suites Lake City by IHG

3.0 star property
8.6 out of 10, Excellent, (1001)
"Great place to stay friendly staff clean rooms"
The price is AU$196
includes taxes & fees
5 Oct - 6 Oct
Holiday Inn & Suites Lake City by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
Photo by Dr__Vlad
Open Photo by Dr__Vlad

Top O Brien Hotel Reviews

More cheap accommodation in O Brien

More cheap accommodation in O Brien

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

450 SW Florida Gateway Drive, Lake City, FL
The price is AU$187 per night from 28 Sept to 29 Sept
AU$187
28 Sept - 29 Sept
includes taxes & fees

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Where is the best place to stay in O Brien?

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Postcard Cabins Gilchrist Springs and Hampton Inn & Suites Lake City. See all available top hotels, or vacation rentals in O Brien.

What are some of the best holiday rentals that O Brien has to offer?

ICHETUCKNEE RIVER - Riverfront on the Crystal Clear Ichetucknee River: This holiday home rental outside of O Brien is located on a river, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 4 bedrooms, as well as a kitchen with a fridge, a stovetop and a microwave, so that you can cook with friends or family. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

What are some accommodation options with pools in O Brien?

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Provides buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Hampton Inn & Suites Lake City and Tru by Hilton Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.

How is it to stay in O Brien?

Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodation options to choose from. Find out more about O Brien.

What are the top places to visit in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.

What's the seasonal weather in O Brien?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.