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6 Dec - 7 Dec
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12 Dec - 14 Dec
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Top hotels and accommodation in O Brien

Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
Alachua
9.4 out of 10, Exceptional, (1002)
"Staff was great and the location is perfect ! "
United States
JAY
The price is AU$192
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Desk, blackout curtains, iron/ironing board, rollaway beds
Americas Best Value Inn Alachua

Americas Best Value Inn Alachua

2.0 star property
Alachua
4.8 out of 10, (597)
"Staff was helpful and so courteous.."
United States
Christian
The price is AU$97
includes taxes & fees
7 Dec - 8 Dec
Americas Best Value Inn Alachua
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
Lake City
8.8 out of 10, Excellent, (1005)
"It was a great hotel! "
United States
Sarah
The price is AU$159
includes taxes & fees
15 Dec - 16 Dec
La Quinta Inn & Suite by Wyndham Lake City
Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

2.5 star property
Alachua
9.4 out of 10, Exceptional, (471)
"Staff very helpful- clean updated facility. "
United States
bethany
The price is AU$161
includes taxes & fees
1 Jan - 2 Jan 2026
Hampton Inn & Suites Alachua I-75
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1000)
"Room was clean and staff was friendly. It's a tad dated but a good place to stop on your way to South Florida "
United States
Dave
The price is AU$140
includes taxes & fees
14 Dec - 15 Dec
Best Western Plus Lake City
Lobby
Comfort Suites Lake City

Comfort Suites Lake City

2.5 star property
Lake City
9.6 out of 10, Exceptional, (1002)
"We love to stop here when traveling to Orlando"
United States
Bridget
The price is AU$175
includes taxes & fees
9 Dec - 10 Dec
Comfort Suites Lake City
Double Room, Non Smoking
High Springs Country Inn

High Springs Country Inn

2.0 star property
High Springs
8.4 out of 10, Very good, (16)
"Great remodel of a retro motel."
United States
Kathleen
The price is AU$119
includes taxes & fees
10 Dec - 11 Dec
High Springs Country Inn
Property amenity
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3.0 star property
Lake City
9.6 out of 10, Exceptional, (173)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
The price is AU$181
includes taxes & fees
28 Dec - 29 Dec
Courtyard By Marriott Lake City
Standard Cabin, 1 Queen Bed | Exterior
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

2.0 star property
High Springs
10.0 out of 10, Exceptional, (146)
"Fantastic place! Very nice amenities and service was wonderful"
United States
Annette
The price is AU$230
includes taxes & fees
7 Dec - 8 Dec
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Exterior
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1002)
"Great place for a restful night when traveling. "
United States
Peggy
The price is AU$148
includes taxes & fees
4 Jan - 5 Jan 2026
Tru by Hilton Lake City
Outdoor pool, pool loungers
Quality Inn Lake City

Quality Inn Lake City

2.5 star property
Lake City
7.8 out of 10, Good, (951)
"very clean room, great staff, we will be staying there again when we come to see our daughter "
United States
Gary
The price is AU$114
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn Lake City
Individually decorated, desk, laptop workspace, iron/ironing board
Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10

2.0 star property
Lake City
6.8 out of 10, (1000)
"Was quite and clean, a little dated but it was a good place to sleep they are pet friendly "
United States
William
The price is AU$102
includes taxes & fees
7 Dec - 8 Dec
Days Inn by Wyndham Lake City I-10
Standard Room, 2 Queen Beds, Non Smoking
Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee

2.5 star property
Live Oak
7.2 out of 10, Good, (612)
"Clean rooms, very friendly staff"
United States
Kristin L
The price is AU$113
includes taxes & fees
1 Jan - 2 Jan 2026
Quality Inn White Springs Suwanee
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

2.5 star property
Lake City
9.0 out of 10, Wonderful, (162)
"Everything was wonderful! We would definitely stay here again. Our favorite place so far!"
United States
Linda
The price is AU$151
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites Lake City
Lobby
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

2.0 star property
Lake City
8.0 out of 10, Very good, (64)
"Great little motel with extremely nice staff. "
United States
Georgiy
The price is AU$88
includes taxes & fees
10 Dec - 11 Dec
Motel 6 – Lake City, Fl – Medical Center
Lobby
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

2.5 star property
Lake City
9.4 out of 10, Exceptional, (1000)
"It was a great stay "
United States
Miranda
The price is AU$159
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn & Suites Lake City
Outdoor pool
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

2.5 star property
Lake City
5.0 out of 10, (1000)
"Just a perfect place to take a break while traveling. Clean,comfortable and a great staff. "
United States
Cris
The price is AU$98
includes taxes & fees
7 Dec - 8 Dec
Baymont by Wyndham Lake City I-75
Reception
BlueGem Motel

BlueGem Motel

2.0 star property
High Springs
9.2 out of 10, Wonderful, (387)
"Great place to stay."
United States
Wesley
The price is AU$184
includes taxes & fees
7 Dec - 8 Dec
BlueGem Motel
Pillow-top beds, in-room safe, desk, blackout curtains
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

2.0 star property
Lake City
7.6 out of 10, Good, (1001)
"Clean room everything I could need staff very nice and helpful I ll be back "
United States
Daphnea
The price is AU$107
includes taxes & fees
8 Dec - 9 Dec
Days Inn by Wyndham Lake City I-75
BBQ/picnic Area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

2.0 star property
Lake City
8.8 out of 10, Excellent, (1002)
"We had a good stay, the room was clean, check in quick and easy, the bed was comfortable."
United States
Alan
The price is AU$114
includes taxes & fees
9 Dec - 10 Dec
Americas Best Value Inn Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Recent Reviews in O Brien

Best Western Plus Lake City

Best Western Plus Lake City

10/10 Excellent
"This will be my go to hotel when traveling to south Florida . Excellent "
Jesse 1-night trip
Posted 4 days ago
Best Western Plus Lake City

More cheap accommodation in O Brien

Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL
The price is AU$140 per night from 14 Dec to 15 Dec
AU$140
14 Dec - 15 Dec
includes taxes & fees
9/10 Wonderful! (1,020 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Best Western Plus Lake City and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. Our travellers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favourite home for rent in O Brien. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Provides buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Best Western Plus Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Bob's River Place and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

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