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Check prices for these dates

This weekend
5 June - 7 June
Next weekend
12 June - 14 June

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Our top choices for O Brien hotels

Individually decorated, desk, laptop workspace, iron/ironing board

1. Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,003 reviews)
"Was ok"
United States
James
The price is AU$99
includes taxes & fees
10 June - 11 June
Days Inn by Wyndham Lake City I-10
Room, 1 King Bed, Accessible, Ground Floor (Mobility) | Accessible bathroom

2. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (721 reviews)
"Loved staying here!! Will definitely visit again!! "
United States
Ashley
The price is AU$113
includes taxes & fees
7 June - 8 June
Super 8 by Wyndham Lake City
Exterior

3. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.6 out of 10, Excellent, (1,115 reviews)
"Enjoyed our stay"
United States
Tammie
The price is AU$155
includes taxes & fees
29 June - 30 June
La Quinta Inn & Suite by Wyndham Lake City
Suite, Multiple Beds, Accessible, Non Smoking

4. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,012 reviews)
"Great stay - easy - accommodating - quiet!"
United States
Paula
The price is AU$179
includes taxes & fees
9 June - 10 June
Comfort Suites Lake City
Lobby

5. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (676 reviews)
"Was great!! Clean rooms and peaceful.. Would stay here again and again.."
United States
Anthony
The price is AU$98
includes taxes & fees
30 June - 1 July
Quality Inn White Springs Suwanee
Breakfast area

6. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (516 reviews)
"Wonderful place to stay"
United States
Tamela
The price is AU$164
includes taxes & fees
14 June - 15 June
Hampton Inn & Suites Alachua I-75
Premium bedding, desk, blackout curtains, soundproofing

7. Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.6 out of 10, Good, (616 reviews)
"REALLY NICE PLACE, VERY CLEAN, WONDERFUL STAFF"
United States
Caroline
The price is AU$102
includes taxes & fees
8 June - 9 June
Palms Garden Inn
Exterior

8. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (223 reviews)
"Amazing spot to be out of the world."
United States
Tati
The price is AU$362
includes taxes & fees
7 July - 8 July
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Exterior

9. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,007 reviews)
"The staff were amazing, great location, big rooms, great breakfast"
United States
Brittani
The price is AU$158
includes taxes & fees
14 June - 15 June
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Reception

10. The Blanche

The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (192 reviews)
"Great property! Beautiful renovated!"
United States
Brandi
The price is AU$215
includes taxes & fees
9 June - 10 June
The Blanche
BBQ/picnic Area

11. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,002 reviews)
"We stopped for one night. We have stayed here before when visiting. The staff is always helpful and accommodating ."
United States
William
The price is AU$112
includes taxes & fees
8 June - 9 June
Americas Best Value Inn Lake City
Pillow-top beds, in-room safe, desk, blackout curtains

12. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,001 reviews)
"Great for a short stay and clean"
United States
Brizheet
The price is AU$107
includes taxes & fees
30 June - 1 July
Days Inn by Wyndham Lake City I-75
Lobby

13. Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (597 reviews)
"older hotel really nicely renovated. Very charmful, comfortable beds. I stayed there because of the reviews and they were accurate. No special amenities' but great value."
United States
William
The price is AU$98
includes taxes & fees
7 June - 8 June
Regal Inn
Exterior

14. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (262 reviews)
"Great location for this small city."
United States
LaShona
The price is AU$188
includes taxes & fees
7 June - 8 June
Courtyard By Marriott Lake City
Snack bar

15. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,011 reviews)
"Clean helpful staff and breakfast was good.parking good also"
United States
John
The price is AU$174
includes taxes & fees
7 June - 8 June
Tru by Hilton Lake City
Lobby sitting area

16. Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
7.6 out of 10, Good, (186 reviews)
"GOOD STOP FOR ONE NIGHT IF BREAKING UP TRAVEL TIME."
United States
Victoria LS
The price is AU$105
includes taxes & fees
7 June - 8 June
Motel 6 – Lake City, Fl – Medical Center
Lobby

17. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,066 reviews)
"Great staff, good room, lovely breakfast"
United States
berendina
The price is AU$161
includes taxes & fees
14 June - 15 June
Best Western Plus Lake City
Lobby

18. Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (304 reviews)
"The room was fairly cheap and staff was friendly."
United States
James
The price is AU$113
includes taxes & fees
23 June - 24 June
Econo Lodge Live Oak
1 bedroom, laptop workspace, free WiFi, bed sheets

19. Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.8 out of 10, Exceptional, (18 reviews)
"Calm peaceful stay, staff was very helpful and attentive. "
United States
Patrick
The price is AU$288
includes taxes & fees
8 June - 9 June
Vista Verde Farm Retreat
Outdoor spa tub

20. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,001 reviews)
"Desk & housekeeping staff were super helpful & friendly!"
United States
Cameron
The price is AU$94
includes taxes & fees
8 June - 9 June
Baymont by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Best Western Plus Lake City

Best Western Plus Lake City

8/10 Good
"This was a quick overnight with quick access to I75. The grounds were clean, there was a nice sitting area outside. The room was clean and what I expected. The bed was comfortable and the pillows were soft just like I like. The breakfast was above average, with the waffle maker and eggs and bacon. It was convenient. I would stay again. Not a perfect 10 because their pool was closed for maintenance and painting and the latte machine was not working."
barbara 1-night trip
Posted 4 hours ago
Best Western Plus Lake City

More cheap accommodation in O Brien

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL
The price is AU$94 per night from 8 June to 9 June
AU$94
8 June - 9 June
includes taxes & fees
5/10 (1,001 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Comfort Suites Lake City. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. Our travellers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favourite home for rent in O Brien. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Features on-the-go, an indoor pool and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Little River Spring Cave divers poolside Hideaway are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

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