Search O Brien hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
21 Apr - 22 Apr
Tomorrow
22 Apr - 23 Apr
This weekend
24 Apr - 26 Apr
Next weekend
1 May - 3 May

Filter by

Guest rating
Guest rating
Star rating

Our top choices for O Brien hotels

Down duvets, pillow-top beds, blackout curtains, free WiFi

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (707 reviews)
"Breakfast included cooked-to order scrambled eggs & sausage."
United States
Patricia
The price is AU$99
includes taxes & fees
13 May - 14 May
Super 8 by Wyndham Lake City
Lobby

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
Live Oak
7.2 out of 10, Good, (663 reviews)
"Great breakfast! The best staff you can get at a hotel!"
United States
vicki
The price is AU$104
includes taxes & fees
5 May - 6 May
Quality Inn White Springs Suwanee
Lobby sitting area

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
8.0 out of 10, Very good, (148 reviews)
"Dog friendly and price."
United States
John
The price is AU$100
includes taxes & fees
22 Apr - 23 Apr
Motel 6 – Lake City, Fl – Medical Center
Premium bedding, desk, blackout curtains, soundproofing

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.4 out of 10, Good, (603 reviews)
"room was clean and the air conditioning worked great would recommend"
United States
david
The price is AU$102
includes taxes & fees
22 Apr - 23 Apr
Palms Garden Inn
Individually decorated, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,002 reviews)
"Low cost but worth it"
United States
Michael
The price is AU$101
includes taxes & fees
22 Apr - 23 Apr
Days Inn by Wyndham Lake City I-10
Double Room, Non Smoking

High Springs Country Inn

High Springs Country Inn
2.0 star property
High Springs
8.4 out of 10, Very good, (26 reviews)
"Friendly and helpful staff, clean room and plenty of parking "
United States
Joseph
The price is AU$115
includes taxes & fees
4 May - 5 May
High Springs Country Inn
1 bedroom, laptop workspace, free WiFi, bed sheets

Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.8 out of 10, Exceptional, (17 reviews)
"Beautiful spot with friendly horses :) "
United States
Dagmara
The price is AU$266
includes taxes & fees
22 Apr - 23 Apr
Vista Verde Farm Retreat
BBQ/picnic Area

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"Clean place to stay "
United States
Michelle
The price is AU$105
includes taxes & fees
27 Apr - 28 Apr
Americas Best Value Inn Lake City
Lobby

Regal Inn

Regal Inn
2.5 star property
Lake City
8.6 out of 10, Excellent, (581 reviews)
"Nice staff, the room was clean and the bed was comfortable. "
United States
Karen
The price is AU$88
includes taxes & fees
23 Apr - 24 Apr
Regal Inn
Exterior

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (203 reviews)
"Perfect getaway for us with our dogs. It was peaceful and relaxing."
United States
Leila
The price is AU$317
includes taxes & fees
21 May - 22 May
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Exterior

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (237 reviews)
"Very nice hotel!"
United States
Travis
The price is AU$172
includes taxes & fees
3 May - 4 May
Courtyard By Marriott Lake City
3 outdoor pools, open 10:00 AM to 10:00 PM, pool loungers

Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.6 out of 10, Excellent, (28 reviews)
"We had a good family getaway and was impressed how the camping experience was . Me and my family had an awesome outdoor experience and we will return again . The people their welcomed you like family and mad the trip and safe "
United States
amy
The price is AU$60
includes taxes & fees
23 Apr - 24 Apr
Suwannee River Rendezvous
Lobby

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,049 reviews)
"Clean room, easy check in/out, friendly staff, friendly staff, simple but delicious breakfast. "
United States
Sara
The price is AU$164
includes taxes & fees
23 Apr - 24 Apr
Best Western Plus Lake City
Lobby

Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (292 reviews)
"Everiting are good"
United States
Jean-louis
The price is AU$100
includes taxes & fees
20 May - 21 May
Econo Lodge Live Oak
Pillow-top beds, in-room safe, desk, blackout curtains

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,005 reviews)
"Quiet comfortable and courteous staff. We Had great time!"
United States
Samantha
The price is AU$105
includes taxes & fees
27 Apr - 28 Apr
Days Inn by Wyndham Lake City I-75
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,003 reviews)
"Great stay, nice area"
United States
Jennifer
The price is AU$163
includes taxes & fees
10 May - 11 May
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Pillow-top beds, desk, iron/ironing board, free WiFi

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very good, (1,005 reviews)
"Great hotel and staff"
United States
Cynthia
The price is AU$121
includes taxes & fees
19 May - 20 May
Quality Inn Lake City
Breakfast area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (502 reviews)
"Breakfast awesome Parking great Staff awesome "
United States
Bryan
The price is AU$161
includes taxes & fees
17 May - 18 May
Hampton Inn & Suites Alachua I-75
Standard Room, 2 Double Beds

Royal Inn

Royal Inn
2.0 star property
Alachua
7.2 out of 10, Good, (194 reviews)
"The room had a bad smell. The towels were worn out both bath towels had holes in them in the surrounding areas are not good. The woman the desk was very. But would not recommend."
United States
mark
The price is AU$91
includes taxes & fees
23 Apr - 24 Apr
Royal Inn
Reception

The Blanche

The Blanche
2.0 star property
Lake City
9.2 out of 10, Wonderful, (183 reviews)
"Loved the hotel and the location! The bed was very very soft and the microfiber sheets were thin and hot!"
United States
Kim
The price is AU$207
includes taxes & fees
5 May - 6 May
The Blanche
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Recent Reviews in O Brien

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

8/10 Good
"Staff writer as friendly with quick check in. Room was clean and comfortable, lots of places to shop and eat nearby, some in walking distance."
Lucinda 1-night trip
Posted 11 hours ago
Motel 6 – Lake City, Fl – Medical Center

More cheap accommodation in O Brien

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

3835 West US Highway 90 Lake City FL
The price is AU$105 per night from 27 Apr to 28 Apr
AU$105
27 Apr - 28 Apr
includes taxes & fees
8.6/10 Excellent! (1,000 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are La Quinta Inn & Suite by Wyndham Lake City and Best Western Plus Lake City. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Offers buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia