
Midtown Holidays
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Your Midtown Holiday
Organising your next getaway just got easier with a holiday package to Midtown. Take in the very best this neighbourhood has to offer while making incredible memories you'll treasure. Your trip to Midtown wouldn't be complete without exploring leading attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Centre. No matter what your dream Midtown holiday looks like, you can make it a reality with Expedia.
Our guide on where to stay in Midtown

Downtown St. Louis
Gourmet restaurants beloved sports teams and top sights from Old Courthouse to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton
Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

Central West End
Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

Creve Coeur
Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

St. Charles Historic District
St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.
Our pick of the best Midtown Hotel Deals

Clayton Plaza Hotel & Extended Stay
"Hotel staff were excellent, friendly, professional and by far the best reason to re-book. The hotel itself was very clean, located near professional buildings/courts and some eateries within walking distance. The room was clean as well and nicely proportioned with some of the best mattresses/bedding ..."
Reviewed on 13 Oct 2026

Pear Tree Inn St. Louis Airport
"The property was great but the breakfast menu was the same every morning. I would’ve liked a little more variety. The happy hour cocktails were nice. The room and property were clean. I would’ve liked highly recommend thus property."
Reviewed on 14 Oct 2026

Drury Plaza Hotel St. Louis at the Arch
"I loved the happy hour, you get a voucher for 3 free alcoholic beverages and the food was delicious."
Reviewed on 13 Oct 2026
Frequently asked questions
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Stay near popular Midtown attractions

St. Louis University
Scott Joplin House State Historic Site
Chaifetz Arena
Harris-Stowe State University
Fubar
Samuel Cupples House
City Foundry STL
Activities

St. Louis Ghost Tour: Sinister Sins & Shadows












