Main Street Tours and Activities

Liam Maguire's Irish Pub & Restaurant with outdoor seating and flower pots.
A restaurant named Martha's with outdoor seating and potted plants.
A large cruise ship on a calm sea with a person sitting on a bench in the foreground.
A marina with several boats docked, a person rowing a boat, and a house in the background.
A large house by the water with several boats.

Top Main Street Hotel & Accommodation Deals

Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod

4 out of 5
1225 Iyannough Rd Hyannis MA
Margaritaville Resort Cape Cod
Craigville Beach Inn

Craigville Beach Inn

2 out of 5
1338 Craigville Beach Rd Centerville MA
Craigville Beach Inn
Hyannis Plaza Hotel

Hyannis Plaza Hotel

2.5 out of 5
662 Main Street Hyannis MA
Hyannis Plaza Hotel
Craigville Beach Compound | 4 Private Suites · Ocean View

Craigville Beach Compound | 4 Private Suites · Ocean View

Barnstable MA
Craigville Beach Compound | 4 Private Suites · Ocean View
The Ocean View

The Ocean View

2.5 out of 5
966 Craigville Beach Road Centerville MA
The Ocean View
Hyannis Harbor Hotel

Hyannis Harbor Hotel

3.5 out of 5
213 Ocean St Hyannis MA
Hyannis Harbor Hotel
Quiet private Centerville cottage, walk to beach, central A/C, parking pass.

Quiet private Centerville cottage, walk to beach, central A/C, parking pass.

Centerville MA
Quiet private Centerville cottage, walk to beach, central A/C, parking pass.
Classic Cape Escape in Charming Cotuit

Classic Cape Escape in Charming Cotuit

Contuit MA
Classic Cape Escape in Charming Cotuit
Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection

4 out of 5
135 Route 28 West Yarmouth MA
Uncommoner Hotel by Reverie Boutique Collection
See all 5,903 properties in Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.