Main Street Fort Pierce Hotels, Fort Pierce

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Check prices for these dates

Tonight
10 Dec - 11 Dec
Tomorrow
11 Dec - 12 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Main Street Fort Pierce hotels

Lobby
Vero Beach Inn & Suites I-95

Vero Beach Inn & Suites I-95

3.0 star property
28 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1317)
"The room was very clean. Staff very courteous. I would stay here again. "
United States
Jesse
Vero Beach Inn & Suites I-95
Outdoor pool, pool umbrellas, pool loungers
Costa d'Este Beach Resort and Spa

Costa d'Este Beach Resort and Spa

4.0 star property
23 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1000)
"Great vibe and location"
United States
Stephanie
The price is AU$486
includes taxes & fees
11 Dec - 12 Dec
Costa d'Este Beach Resort and Spa
Free daily on-the-go breakfast
Flamingo inn and suites

Flamingo inn and suites

2.5 star property
28.6 km from Main Street Fort Pierce
7.4 out of 10, Good, (1000)
"Clean room convenient decent breakfast "
United States
Andrew
The price is AU$144
includes taxes & fees
11 Dec - 12 Dec
Flamingo inn and suites
Breakfast, lunch, dinner served; American cuisine, beach views
Ocean Breeze Inn Vero Beach

Ocean Breeze Inn Vero Beach

3.5 star property
23.2 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1086)
"Love love this place! Most definitely will be back! "
United States
Silvia
The price is AU$239
includes taxes & fees
11 Dec - 12 Dec
Ocean Breeze Inn Vero Beach
Exterior
Howard Johnson by Wyndham Vero Beach / Downtown

Howard Johnson by Wyndham Vero Beach / Downtown

2.0 star property
21.7 km from Main Street Fort Pierce
7.0 out of 10, Good, (1000)
"Very good"
United States
Carlos
The price is AU$159
includes taxes & fees
22 Dec - 23 Dec
Howard Johnson by Wyndham Vero Beach / Downtown
Exterior
Kimpton Vero Beach Hotel & Spa by IHG

Kimpton Vero Beach Hotel & Spa by IHG

4.0 star property
23.4 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1001)
"Extremely friendly hosts and beautiful hotel "
United States
Aaron
The price is AU$431
includes taxes & fees
6 Jan - 7 Jan 2026
Kimpton Vero Beach Hotel & Spa by IHG
Outdoor pool, pool loungers
Best Western Port St. Lucie

Best Western Port St. Lucie

2.5 star property
14 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1000)
"Love this place. Great place with a lot of space."
United States
Bradley
The price is AU$161
includes taxes & fees
23 Dec - 24 Dec
Best Western Port St. Lucie
Exterior
Holiday Inn Express - Vero Beach by IHG

Holiday Inn Express - Vero Beach by IHG

2.5 star property
28.8 km from Main Street Fort Pierce
8.2 out of 10, Very good, (839)
"I like the room it was clean and also not a smell at cigarette or other kind of smell. It was nice."
United States
Maria
The price is AU$179
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express - Vero Beach by IHG
Exterior
Comfort Suites Vero Beach I-95

Comfort Suites Vero Beach I-95

2.5 star property
28.4 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1002)
"Very clean and attractive room, staff was very friendly."
United States
Jean
The price is AU$182
includes taxes & fees
17 Dec - 18 Dec
Comfort Suites Vero Beach I-95
3 outdoor pools, open 7:00 AM to 10:00 PM, pool umbrellas, pool loungers
Marriott Hutchinson Island Beach Resort, Golf & Marina

Marriott Hutchinson Island Beach Resort, Golf & Marina

4.0 star property
29.8 km from Main Street Fort Pierce
8.2 out of 10, Very good, (382)
"The room was awesome and the location was great. "
United States
Robin
The price is AU$348
includes taxes & fees
14 Dec - 15 Dec
Marriott Hutchinson Island Beach Resort, Golf & Marina
Sun deck
Prestige Hotel Vero Beach

Prestige Hotel Vero Beach

2.0 star property
20.5 km from Main Street Fort Pierce
8.4 out of 10, Very good, (1001)
"Great place"
United States
Rosa
The price is AU$234
includes taxes & fees
11 Dec - 12 Dec
Prestige Hotel Vero Beach
Outdoor spa tub
Hutchinson Island Hotel

Hutchinson Island Hotel

2.5 star property
3.1 km from Main Street Fort Pierce
8.4 out of 10, Very good, (1361)
"The breakfast and view is the best!"
United States
Marisa
Hutchinson Island Hotel
Terrace/patio
Home2 Suites by Hilton Vero Beach I-95

Home2 Suites by Hilton Vero Beach I-95

3.0 star property
28.3 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (431)
"Rooms were clean, the staff was amazing. Great stay!"
United States
Danielle
The price is AU$185
includes taxes & fees
23 Dec - 24 Dec
Home2 Suites by Hilton Vero Beach I-95
On the beach, sun-loungers, beach umbrellas, beach towels
Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa

4.0 star property
25.2 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1000)
"Room was clean and comfortable, staff was very kind and helpful, I will definitely visit again "
United States
Andrekiss
The price is AU$402
includes taxes & fees
22 Dec - 23 Dec
Hutchinson Shores Resort & Spa
BBQ/picnic Area
Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie

3.0 star property
17.8 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1000)
"Great stay! Very friendly staff "
United States
Giovanni
The price is AU$199
includes taxes & fees
18 Dec - 19 Dec
Residence Inn by Marriott Port St. Lucie
Exterior
SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie

3.0 star property
17.2 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1002)
"Great stay"
United States
Craig
The price is AU$147
includes taxes & fees
15 Dec - 16 Dec
SpringHill Suites Port St. Lucie
Exterior
Hampton Inn & Suites Stuart-North

Hampton Inn & Suites Stuart-North

2.5 star property
26.1 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1001)
"The best possible stay in every way."
United States
Erinn
The price is AU$161
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn & Suites Stuart-North
Lobby
Mainstay Suites at PGA Village

Mainstay Suites at PGA Village

2.5 star property
18 km from Main Street Fort Pierce
6.4 out of 10, (816)
"It was a good stay."
United States
Miranda L
The price is AU$113
includes taxes & fees
17 Dec - 18 Dec
Mainstay Suites at PGA Village
Courtyard
Star Suites: An Extended Stay Hotel

Star Suites: An Extended Stay Hotel

2.5 star property
24.3 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (566)
"Was perfect for our trip, will stay again! "
United States
Christopher
The price is AU$168
includes taxes & fees
25 Dec - 26 Dec
Star Suites: An Extended Stay Hotel
Property amenity
Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG

3.0 star property
24.1 km from Main Street Fort Pierce
9.8 out of 10, Exceptional, (571)
"I would definitely stay at this place again great people great atmosphere very clean"
United States
Kristi
The price is AU$234
includes taxes & fees
22 Dec - 23 Dec
Staybridge Suites Vero Beach by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas for the activities you enjoy most.

Lakewood Park

When in Lakewood Park, you can plan a visit to Lakewood Park Regional Park / Pool and McKee Botanical Garden, some noteworthy sights in the nearby area.

Spanish Lakes Country Club Village

While Spanish Lakes Country Club Village isn't home to many top sights, Lakewood Park Regional Park / Pool and McKee Botanical Garden are some notable places to visit nearby.

Spanish Lakes Fairways

While there might not be top attractions in Spanish Lakes Fairways, you can explore the larger area and discover places like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

Meadowood

While Meadowood isn't home to many top sights, Endless Summer Vineyard & Winery and Lakewood Park Regional Park / Pool are some notable places to visit nearby.

Panther Woods

While Panther Woods may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Endless Summer Vineyard & Winery and Lakewood Park Regional Park / Pool.

Top Main Street Fort Pierce Hotel Reviews

Motel 6 Ft. Pierce, FL, Fort Pierce

Motel 6 Ft. Pierce, FL, Fort Pierce

10/10 Excellent
"The charger ports not working to charge our phone spoke to management nothing was done the toilet kept getting clogged up I was annoyed and still is I’m doing extended stay "
Cassandra 1-night trip
Posted 1 day ago
Motel 6 Ft. Pierce, FL, Fort Pierce

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighbourhood that travellers like for its waterfront, art and shopping. Make sure that you visit Downtown Fort Pierce and Sunrise Theater as part of your Main Street Fort Pierce travel plans.
How many hotels will I find in Main Street Fort Pierce?
Book one of Expedia's 5 hotels and other accommodation options in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! Most room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best options available in Main Street Fort Pierce.
What is there to do in this Fort Pierce neighbourhood?
For cultural attractions in Main Street Fort Pierce, head to Sunrise Theater, Art Mundo and Official Highwaymen Art Gallery. Downtown Fort Pierce and Fort Pierce City Marina are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Main Street Fort Pierce include Fort Pierce Farmer's Market, Manatee Education and Observation Center and House of Seven Gables. A.E. Backus Museum and Marina at Fort Pierce are also worth a visit when you're out sightseeing in Fort Pierce.