Main Street Fort Pierce Hotels, Fort Pierce

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
9 Nov - 10 Nov
Tomorrow
10 Nov - 11 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Main Street Fort Pierce hotels

A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

1. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (909 reviews)
"Clean rooms and bathrooms, breakfast and ample parking. The staff was very helpful as well"
United States
Dorisbell
The price is AU$179
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

2. Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
7.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,005 reviews)
"Even though the property is undergoing renovation, it was very clean and the staff are so nice."
United States
Don
The price is AU$151
includes taxes & fees
15 Nov - 16 Nov
Fairfield Inn & Suites by Marriott Fort Pierce
A beach with a wooden pier, a thatched-roof structure, and beach chairs.

3. Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,373 reviews)
"Clean room nice staff and awesome view!! Will be staying there again soon!"
United States
Lana
The price is AU$196
includes taxes & fees
3 Dec - 4 Dec
Hutchinson Island Hotel
A modern hotel lobby with a central seating area, a bar, and a coffee station.

4. Hampton Inn & Suites Ft. Pierce

Hampton Inn & Suites Ft. Pierce
2.5 star property
7.9 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,000 reviews)
"Rooms & common areas were clean & breakfast was good with a wide variety to choose from. Would stay here again."
United States
Ashton
The price is AU$151
includes taxes & fees
23 Nov - 24 Nov
Hampton Inn & Suites Ft. Pierce
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

5. La Quinta Inn & Suites by Wyndham Ft. Pierce

La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
7.9 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,006 reviews)
"Great property and service but they allow dogs to stay in the hotel and getting awaken by barking dogs is a no go"
United States
Willie
The price is AU$144
includes taxes & fees
15 Nov - 16 Nov
La Quinta Inn & Suites by Wyndham Ft. Pierce
A hotel room with two beds, a nightstand, a wall-mounted lamp, and a sunset view painting.

6. Days Inn & Suites by Wyndham Fort Pierce Midtown

Days Inn & Suites by Wyndham Fort Pierce Midtown
2.0 star property
4.5 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (18 reviews)
"Very clean and convenient."
United States
Gary
The price is AU$115
includes taxes & fees
11 Nov - 12 Nov
Days Inn & Suites by Wyndham Fort Pierce Midtown
An outdoor seating area with fire feature, stone walls, and a view into the building.

7. Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (280 reviews)
"Wet nice"
United States
Cheryl
The price is AU$207
includes taxes & fees
22 Nov - 23 Nov
Home2 Suites by Hilton Ft. Pierce I-95
A hotel entrance with a welcome sign, a black mat, and two potted plants.

8. At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,388 reviews)
"Everything was great!"
United States
John
The price is AU$87
includes taxes & fees
8 Dec - 9 Dec
At Home Inn
A hotel room with a bed, a sofa, and a small table. There are framed pictures on the wall.

9. Comfort Suites Fort Pierce I-95

Comfort Suites Fort Pierce I-95
2.5 star property
7.7 km from Main Street Fort Pierce
7.8 out of 10, Good, (981 reviews)
"Good"
United States
Jasqueze
The price is AU$150
includes taxes & fees
11 Nov - 12 Nov
Comfort Suites Fort Pierce I-95
A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

10. SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
17.2 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,001 reviews)
"Loved our stay, great staff."
United States
Amy
The price is AU$144
includes taxes & fees
15 Nov - 16 Nov
SpringHill Suites Port St. Lucie
A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

11. Royal Inn Beach Hotel Hutchinson Island

Royal Inn Beach Hotel Hutchinson Island
2.5 star property
3.8 km from Main Street Fort Pierce
7.2 out of 10, Good, (1,002 reviews)
"Property and staff were great. Convenient place to stay if visiting Fort Pierce. I would definitely book again."
United States
Malia
The price is AU$200
includes taxes & fees
10 Nov - 11 Nov
Royal Inn Beach Hotel Hutchinson Island
A modern living room with a fireplace, a dining area with bar stools, and a large TV mounted on the wall.

12. Hampton Inn & Suites Vero Beach Downtown

Hampton Inn & Suites Vero Beach Downtown
2.5 star property
22.1 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,000 reviews)
"Everything was excellent."
United States
Judith
The price is AU$199
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn & Suites Vero Beach Downtown
A hotel lobby with a reception desk, a chandelier, a clock, and a sofa.

13. Sleep Inn Fort Pierce I-95

Sleep Inn Fort Pierce I-95
2.5 star property
7.9 km from Main Street Fort Pierce
7.6 out of 10, Good, (927 reviews)
"Staff was very friendly and rooms were clean"
United States
Charity
The price is AU$121
includes taxes & fees
29 Nov - 30 Nov
Sleep Inn Fort Pierce I-95
A hotel lobby with seating areas, a kitchenette, and a view of the outdoors.

14. Hampton Inn & Suites Port St. Lucie, West

Hampton Inn & Suites Port St. Lucie, West
2.5 star property
17.4 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,009 reviews)
"Very Helpful and Friendly staff, our room was super clean, and breakfast was great!"
United States
Ahim
The price is AU$158
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn & Suites Port St. Lucie, West
A reception area with a wooden reception desk, a bulletin board with various notices, a window with blinds, and a wall-mounted security camera.

15. Rodeway Inn Fort Pierce US Highway 1

Rodeway Inn Fort Pierce US Highway 1
2.0 star property
2.9 km from Main Street Fort Pierce
6.8 out of 10, (126 reviews)
"Worked"
United States
Steven
The price is AU$139
includes taxes & fees
13 Nov - 14 Nov
Rodeway Inn Fort Pierce US Highway 1
A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

16. Days Inn & Suites by Wyndham Fort Pierce I-95

Days Inn & Suites by Wyndham Fort Pierce I-95
2.5 star property
7.8 km from Main Street Fort Pierce
7.4 out of 10, Good, (1,000 reviews)
"The staff was excellent"
United States
Carlton
The price is AU$96
includes taxes & fees
29 Nov - 30 Nov
Days Inn & Suites by Wyndham Fort Pierce I-95
A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

17. Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
14 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,004 reviews)
"Great stay"
United States
Patrisha
The price is AU$147
includes taxes & fees
22 Nov - 23 Nov
Best Western Port St. Lucie
An outdoor seating area with wicker furniture, a fire pit, and palm trees.

18. Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
24.1 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (728 reviews)
"Perfect stay"
United States
Michelle
The price is AU$202
includes taxes & fees
15 Nov - 16 Nov
Staybridge Suites Vero Beach by IHG
A hotel room with a large bed, a desk, a chair, a bathroom, and a hallway.

19. Red Roof Inn Ft Pierce

Red Roof Inn Ft Pierce
2.0 star property
4.6 km from Main Street Fort Pierce
7.2 out of 10, Good, (819 reviews)
"Great place to stay as a family the day staff was wonderful when my hubby went to ask for an extra towel he was only given a had towel then had a fall in the shower due to no grip in the tub/shower but the room was up to par for the price pool was even still open"
United States
Sam
The price is AU$124
includes taxes & fees
10 Nov - 11 Nov
Red Roof Inn Ft Pierce
A Holiday Inn Express & Suites hotel with a modern design, featuring a prominent entrance, well-maintained landscaping, and a clear view of the sky.

20. Holiday Inn Express & Suites Port St. Lucie West by IHG

Holiday Inn Express & Suites Port St. Lucie West by IHG
2.5 star property
17.1 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,002 reviews)
"My stays there was pretty cool !!"
United States
Pierre Guens
The price is AU$192
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express & Suites Port St. Lucie West by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in Main Street Fort Pierce

A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

2.5 star property
8.3 km from Main Street Fort Pierce
View
A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

Fairfield Inn & Suites by Marriott Fort Pierce

3.0 star property
7.7 km from Main Street Fort Pierce
View
A beach with a wooden pier, a thatched-roof structure, and beach chairs.

Hutchinson Island Hotel

2.5 star property
3.1 km from Main Street Fort Pierce
View
A modern hotel lobby with a central seating area, a bar, and a coffee station.

Hampton Inn & Suites Ft. Pierce

2.5 star property
7.9 km from Main Street Fort Pierce
View
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

La Quinta Inn & Suites by Wyndham Ft. Pierce

3.0 star property
7.9 km from Main Street Fort Pierce
View
9.0
Wonderful
909 reviews
8.8
Excellent
1,005 reviews
8.2
Very good
1,373 reviews
9.2
Wonderful
1,000 reviews
8.6
Excellent
1,006 reviews
The price is AU$179
includes taxes & fees
15 Nov - 16 Nov
The price is AU$151
includes taxes & fees
15 Nov - 16 Nov
The price is AU$196
includes taxes & fees
3 Dec - 4 Dec
The price is AU$151
includes taxes & fees
23 Nov - 24 Nov
The price is AU$144
includes taxes & fees
15 Nov - 16 Nov
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • No WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking

Our guide on where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas for the activities you enjoy most.
A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

When in Lakewood Park, you can plan a visit to McKee Botanical Garden and Avalon State Park, some noteworthy sights in the nearby area.

Spanish Lakes Country Club Village

While Spanish Lakes Country Club Village isn't home to many top sights, Harbor Branch Ocean Discovery Center and McKee Botanical Garden are some notable places to visit nearby.

A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While there might not be top attractions in Spanish Lakes Fairways, you can explore the larger area and discover places like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

While Meadowood isn't home to many top sights, Endless Summer Vineyard & Winery and Al's Family Farms are some notable places to visit nearby.

A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

While Panther Woods may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Endless Summer Vineyard & Winery and Al's Family Farms.

Frequently Asked Questions

What is Main Street Fort Pierce like?

Main Street Fort Pierce is a neighbourhood that travellers like for its waterfront, art and shopping. Make sure that you visit Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.

How many hotels will I find in Main Street Fort Pierce?

Book one of Expedia's 7 hotels and other accommodation options in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.

If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?

Yes! Most room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best options available in Main Street Fort Pierce.

What is there to do in this Fort Pierce neighbourhood?

Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.