Holiday Homes in Los Santos

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Featured Holiday Homes in Los Santos

Best location directly on Playa Venao with private pool, Sleeps 11+

8.0 out of 10, Very good, (2)
"I very rarely give 5 starts and this place doesn't deserve 5 but close is fair. When you drive-up to the property, you can see straight-through to the infinity pool and ocean -- it's a lovely location. (The 5 hour drive is grueling from Panama City). However, they have lots of rules and lacking some basic kitchen supplies. First thing to know is the A/C IS ONLY IN THE BEDROOMS! and they mention several times to turn it off ($900 electric bill, they cry, as if I haven't just spent over $4000 to...
Best location directly on Playa Venao with private pool, Sleeps 11+

Beachfront Villa in Decameron

10.0 out of 10, Exceptional, (1)
"Quiet and peaceful beach front property. The person who assisted us during the stay was very helpful and went above and beyond. "
The price is AU$390
includes taxes & fees
21 Aug - 22 Aug
Beachfront Villa in Decameron

Santa Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama.

10.0 out of 10, Exceptional, (1)
"Our stay at this beautiful property in El Chiru, Panama, was nothing short of amazing! The house is impeccably clean, well-maintained, and equipped with everything we needed for a comfortable and relaxing stay. Nice neighborhood, serene atmosphere and super close to the beach which is beautiful tooThe hosts were also fantastic—super responsive, friendly, and helpful with local tips and recommendations. We felt genuinely welcomed and well taken care of"
Santa Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama.

GoldSky Hacienda with pool

10.0 out of 10, Exceptional, (1)
GoldSky Hacienda with pool

Beach House / 6 People / Pool / Pet Friendly / Tourist Area

8.0 out of 10, Very good, (1)
"Todo muy bien ordenado y cómodo. Buena comunicación con la anfitriona."
Beach House / 6 People / Pool / Pet Friendly / Tourist Area

Santa Clara ocean front beach house… from your lawn right onto the sand.

10.0 out of 10, Exceptional, (6)
"Very friendly and forthcoming host beautiful host"
Santa Clara ocean front beach house… from your lawn right onto the sand.

Marina garden bbq private pool

2.0 star property
Marina garden bbq private pool

Beautiful Beach House and Casita at Playa Uverito, Las Tablas Panama

9.2 out of 10, Wonderful, (5)
"Everything was as advertised, great location with a beautiful view. This is our second year staying here and there were several upgrades that made our stay better. Looking forward to our next visit to the beach."
Beautiful Beach House and Casita at Playa Uverito, Las Tablas Panama

Residence 51 - Blue Venao A luxury 4 bedroom 4.5 bathroom beachfront residence

10.0 out of 10, Exceptional, (1)
"Everything about our stay was idyllic. As one of 3 houses on the beach, the location could not be more ideal. The house is beautifully appointed and maintained. I would highly recommend Blue Venao 51."
Residence 51 - Blue Venao A luxury 4 bedroom 4.5 bathroom beachfront residence

Amazing House in Pedasi with Pool and Beautiful Views

10.0 out of 10, Exceptional, (1)
"This home was truly the best home we ever stayed! Angela and Paul were absolutely wonderful! The pictures are beautiful, but let me tell you to see it in real life it is stunning We had everything we would need! Riccardo the house manager was available and super friendly! The kids enjoyed the pool, the ocean front was just a short walk away and breathtaking! The community was small and totally relaxing! There is so much to do within a short drive! We would absolutely rent from here again!!"
Amazing House in Pedasi with Pool and Beautiful Views

Panama Santa Clara Beach Residence

9.6 out of 10, Exceptional, (4)
"Le propriétaire de la maison Gigi, Roger, est très disponible en tout temps pour les questions et les situations difficiles tel que la Covid 19. qui a malheureusement précipité notre départ après un mois. La réception à l'Aéroport de Rio Hato par notre ange gardien Benito, présent en tout temps à proximité de la propriété fût très apprécié. La sécurité ressentie fût impeccable. Notre famille composé d'enfants et de petits enfants, ainsi que nous, (12 personnes) avons très apprécié l'espace et...
Panama Santa Clara Beach Residence

Stunning Beachfront Home near Cambutal Beach Break

Stunning Beachfront Home near Cambutal Beach Break

Villa Perla, A Surfer's Dream

2.0 star property
Villa Perla, A Surfer's Dream

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

10.0 out of 10, Exceptional, (2)
"We absolutely loved our stay here! This was the best vacation rental we've stayed in throughout Panama. Philip and Olga were very responsive, friendly, and accommodating. We highly recommend this place to everyone!"
Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

Minimalist House In Chitre

Minimalist House In Chitre

Modern Beach Home with pool and hot tub

10.0 out of 10, Exceptional, (1)
"excelente"
Modern Beach Home with pool and hot tub

Beautiful Home in Residenciales Cubita

10.0 out of 10, Exceptional, (2)
"This house is so beautiful and comfortable, spacious and has great areas to chill and rest. The area around the house is very calm and quiet. Ivette is an amazing host, very responsive and was attentive to everything we needed during our stay. Will Definitely stay here again. "
Beautiful Home in Residenciales Cubita

Susan Fish Camp in Playa Morrillo, Veraguas

10.0 out of 10, Exceptional, (7)
"The host, Asta, was easy to communicate with. She responded promptly. Asta knows the area well and was very helpful. The property is as represented on Vrbo. Beautiful setting with wonderful view of the ocean. Nice small pool. We will return."
Susan Fish Camp in Playa Morrillo, Veraguas

Vila Sueño Azul - Blue Venao 3BR

The price is AU$419
includes taxes & fees
21 Aug - 22 Aug
Vila Sueño Azul - Blue Venao 3BR

Luxury Villa in Buenaventura

Luxury Villa in Buenaventura
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Los Santos Hotel Reviews