Photo by Lisa Travelfeet

Spa Hotels & Resorts in Los Osos from AU$228

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Los Osos Spa Hotels

Tonight
24 Dec - 25 Dec
Tomorrow
25 Dec - 26 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Our top choices for Los Osos hotels with a spa

Outdoor pool
Sea Pines Resort

Sea Pines Resort

Sea Pines Resort
3.0 star property
Los Osos
8.2 out of 10, Very good, (411)
"Nice staff."
United States
Ann
Sea Pines Resort
Caveman | Bathroom
Madonna Inn

Madonna Inn

Madonna Inn
3.5 star property
San Luis Obispo
9.2 out of 10, Wonderful, (1338)
"Great place."
United States
Caeli
The price is AU$268
includes taxes & fees
4 Jan - 5 Jan 2026
Madonna Inn
Property entrance
Avila Village Inn

Avila Village Inn

Avila Village Inn
3.5 star property
Avila Beach
9.2 out of 10, Wonderful, (1001)
"We really enjoyed our stay-room was clean-lobby was cozy and the entire place has tons of character!! "
United States
Alfredo
Avila Village Inn
Restaurant
The Agrarian Hotel, BW Signature Collection

The Agrarian Hotel, BW Signature Collection

The Agrarian Hotel, BW Signature Collection
2.5 star property
Arroyo Grande
9.6 out of 10, Exceptional, (1012)
"The staff was very friendly, the breakfast was yummy, and the room was very clean. I would definitely stay here again."
United States
Vanessa
The price is AU$228
includes taxes & fees
28 Dec - 29 Dec
The Agrarian Hotel, BW Signature Collection
Reception
HOTEL CERRO, Autograph Collection

HOTEL CERRO, Autograph Collection

HOTEL CERRO, Autograph Collection
4.0 star property
Downtown San Luis Obispo
9.2 out of 10, Wonderful, (470)
"Excellent! So accommodating and eager to offer top notch service. Early check in, great referrals into town and spotless!"
United States
Melissa
The price is AU$408
includes taxes & fees
25 Dec - 26 Dec
HOTEL CERRO, Autograph Collection
Suite, Private Bathroom, (CALIFORNIA KING PATIO - West) | City view
Inn at Rose's Landing

Inn at Rose's Landing

Inn at Rose's Landing
2.0 star property
Downtown Morro Bay
8.0 out of 10, Very good, (1)
The price is AU$323
includes taxes & fees
30 Dec - 31 Dec
Inn at Rose's Landing
Exterior
Cayucos Sunset Inn B&B

Cayucos Sunset Inn B&B

Cayucos Sunset Inn B&B
3.5 star property
Cayucos
9.8 out of 10, Exceptional, (197)
"Great place to stay"
United States
Jason
The price is AU$278
includes taxes & fees
5 Jan - 6 Jan 2026
Cayucos Sunset Inn B&B
Property grounds
Avila La Fonda Hotel

Avila La Fonda Hotel

Avila La Fonda Hotel
4.0 star property
Avila Beach
9.6 out of 10, Exceptional, (1001)
"Very nice hotel. Great for and rest and relaxation kind of vacation"
United States
Princess
The price is AU$301
includes taxes & fees
4 Jan - 5 Jan 2026
Avila La Fonda Hotel
Morro Suite | Living area
Hotel San Luis Obispo

Hotel San Luis Obispo

Hotel San Luis Obispo
4.5 star property
Downtown San Luis Obispo
9.4 out of 10, Exceptional, (559)
"Great space, friendly staff and good restaurants - we thoroughly enjoyed ourselves. "
United States
michelle
The price is AU$589
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel San Luis Obispo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Los Osos Hotel Reviews

Embassy Suites by Hilton San Luis Obispo

Embassy Suites by Hilton San Luis Obispo

10/10 Excellent
"Nice "
Helen 1-night trip
Posted 18 hours ago
Embassy Suites by Hilton San Luis Obispo

Frequently asked questions

Looking for a spa hotel in Los Osos?
Forget the stress of everyday life and book yourself a hotel with a spa. Discover the beaches in Los Osos—worth a picture or two! Take part in recreational activities such as golf during your holiday. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Los Osos?
Sea Pines Resort is a top spa hotel featuring a golf course, a bar and a restaurant. Spend an afternoon at the spa where you'll find deep-tissue massages, hot stone massages and couples treatments.
How many spa hotels will I find in Los Osos?
Among Expedia's 42 accommodation options in Los Osos, there is 1 spa hotel.
What's there to see and do in Los Osos?
Experience Los Osos with a stop at Los Osos Oaks State Reserve, Elfin Forest Preserve and Montaña de Oro State Park. If you have a bit of extra time while you're in the area, you might want to check out Morro Bay State Park and Morro Coast Audubon Society Sweet Springs Nature Preserve.
What is a Los Osos spa hotel?
Spa hotels in Los Osos provide lodging and have an on-site spa which offers services such as facials as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.