The best area to stay in Knox City is near the town centre, particularly around the intersection of US-82 and US-277.
This area provides the most convenient access to local amenities. You'll find the main cluster of businesses, including the grocery store, a few local eateries, and the city's public park, all within a short drive. The general layout is a grid pattern, making it easy to navigate.
For solo travellers or couples passing through, staying in this central area simplifies finding a place to eat and getting back on the main roads quickly.