
Isolotto Holidays
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Your Isolotto Holiday
Reserving a tailor-made Isolotto holiday package is a good way to know the ins and outs of this unique neighbourhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next holiday to Isolotto, Expedia is here to help.
Our guide on where to stay in Isolotto

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza di Santa Maria Novella or Via de' Calzaiuoli while you're exploring the neighbourhood.

Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

San Giovanni
If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Croce
Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.
Our pick of the best Isolotto Hotel Deals

Plus Florence - Hostel

The Social Hub Florence Lavagnini

The Social Hub Florence Belfiore
"The rooms were clean and comfortable, and the staff were amazing—very friendly and helpful. We arrived late, so we had to do a self check-in, but it wasn’t bad at all. There was someone available to give us directions and help us figure everything out. Our rooms were located in the building next ..."
Reviewed on 5 Sept 2026
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Activities

City Sightseeing Florence Hop-on Hop-off Bus Tour

Small-Group Wine Tasting Experience in the Tuscan Countryside











