
Isolotto Holidays
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Your Isolotto Holiday
Reserving a tailor-made Isolotto holiday package is a good way to know the ins and outs of this unique neighbourhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next holiday to Isolotto, Expedia is here to help.
Our guide on where to stay in Isolotto

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Our pick of the best Isolotto Hotel Deals

The Social Hub Florence Lavagnini
Reviewed on 2 Aug. 2025

c-hotels Ambasciatori
Reviewed on 23 Jul. 2025

Hotel Machiavelli Palace
Reviewed on 31 Jul. 2025
Frequently asked questions
Discover the most popular places to visit in Isolotto

Uffizi Gallery
A visit to Florence’s famous art gallery will bring you face to face with some of the world’s best-loved masterpieces.

Ponte Vecchio
The shop-lined Ponte Vecchio over the River Arno is one of Florence’s most familiar and most romantic landmarks.

Cathedral of Santa Maria del Fiore
The magnificent dome of Santa Maria del Fiore provides the Florentine skyline with one of its most iconic outlines.
Activities

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Cinque Terre and Pisa Day Trip from Florence
