Good Day Sunshine Early Morning Sunshine passes through the fog and scatters through the leaves of a tree in Scott County Missouri

Independent in Sikeston

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
12 June - 14 June
Next weekend
19 June - 21 June
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Sikeston Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Our stay was amazing! The breakfast and kickback were really good. The only complaint was the AC in our suite only really cooled the bedroom."
Jessica 2-night trip
Posted 13 hours ago
Drury Inn & Suites Sikeston, MO